{"id":"W4282946854","doi":"10.1016/j.biopsych.2022.05.030","title":"Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Institute on Aging; Data Science Institute, Columbia University; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; New York State Stem Cell Science; Office of Naval Research; Hope for Depression Research Foundation; U.S. Department of Veterans Affairs","keywords":"Fluoxetine; Proenkephalin; Dentate gyrus; Antidepressant; Pharmacology; Reuptake inhibitor; Opioid; Endocrinology; Internal medicine; Enkephalin; Receptor; Serotonin; Medicine; Hippocampal formation; Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133371,0.0002212098,0.0002245212,0.0002870412,0.0003629401,0.0003419914,0.000210983,0.0002805336,0.001655137],"category_scores_gemma":[0.0001779442,0.0001143117,0.0001840106,0.0001026452,0.0003310002,0.0001882083,0.0002190929,0.0004790734,0.00009238051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004860819,"about_ca_system_score_gemma":0.0005211468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006057841,"about_ca_topic_score_gemma":0.01343274,"domain_scores_codex":[0.9999403,0.00001471043,0.000004007087,0.0000067397,0.00001438719,0.00001978187],"domain_scores_gemma":[0.9999301,0.00001659467,0.00001899966,0.000005242512,0.0000125151,0.00001657382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002871959,0.0003422271,0.01356005,0.0009656983,0.0002549993,0.002147327,0.0003223933,0.0007312426,0.7622024,0.007944585,0.00089019,0.2077669],"study_design_scores_gemma":[0.000243161,0.004298408,0.7979717,0.0003272117,0.0005597123,0.003973151,0.0008257265,0.003101389,0.1606252,0.004938886,0.02308216,0.00005337566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9263187,0.0553267,0.001831455,0.001438968,0.0001014278,0.00005164956,0.0002406365,0.0000302271,0.0146601],"genre_scores_gemma":[0.9754438,0.01988256,0.0008094771,0.0002117976,0.00008908899,0.00002185305,0.00008825695,0.000003605211,0.003449577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006057841,"threshold_uncertainty_score":0.01204515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656926571334003,"score_gpt":0.2352393824187629,"score_spread":0.2186701167054229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}