{"id":"W4282946854","doi":"10.1016/j.biopsych.2022.05.030","title":"Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Institute on Aging; Data Science Institute, Columbia University; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; New York State Stem Cell Science; Office of Naval Research; Hope for Depression Research Foundation; U.S. Department of Veterans Affairs","keywords":"Fluoxetine; Proenkephalin; Dentate gyrus; Antidepressant; Pharmacology; Reuptake inhibitor; Opioid; Endocrinology; Internal medicine; Enkephalin; Receptor; Serotonin; Medicine; Hippocampal formation; Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002277375,0.0001022903,0.0001881609,0.00002523198,0.0002926512,0.000005845553,0.000595717,0.00003071687,0.00001837987],"category_scores_gemma":[0.0005994063,0.00004851504,0.0001319946,0.0003642539,0.00007613542,0.000009975258,0.0004336973,0.0001477328,0.000006274037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001154926,"about_ca_system_score_gemma":0.00002435842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004020394,"about_ca_topic_score_gemma":6.203121e-7,"domain_scores_codex":[0.9983091,0.0006844912,0.0002638119,0.0002846805,0.000279761,0.000178116],"domain_scores_gemma":[0.9989555,0.000455315,0.0001845957,0.0003405659,0.00002427483,0.00003970955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001023963,0.0001404603,0.002943051,0.00003509531,0.000002555111,0.000002501665,0.00001176654,0.0001091501,0.9560649,0.04015288,0.0003701619,0.00006509683],"study_design_scores_gemma":[0.0002959674,0.0006812158,0.02914487,0.00002458932,0.00001349373,0.00002964091,0.00002834254,0.0001043083,0.9671916,0.000121994,0.002295316,0.00006868967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952027,0.0001290664,0.0002391832,0.00050162,0.00316157,0.000611168,0.00006454618,0.00003349252,0.00005660973],"genre_scores_gemma":[0.9986649,0.00001043499,0.00002575847,0.001158375,0.00007029405,0.00005214199,6.286108e-7,0.000006513319,0.0000109977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04003088,"threshold_uncertainty_score":0.2250866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656926571334003,"score_gpt":0.2352393824187629,"score_spread":0.2186701167054229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}