{"id":"W4282947280","doi":"10.3390/brainsci12060781","title":"Selective Probiotic Treatment Positively Modulates the Microbiota–Gut–Brain Axis in the BTBR Mouse Model of Autism","year":2022,"lang":"en","type":"article","venue":"Brain Sciences","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Alberta Children's Hospital; Lallemand (Canada); University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Canadian Institutes of Health Research; University of Calgary; Cumming School of Medicine, University of Calgary; Alberta Children's Hospital Research Institute","keywords":"Gut flora; Probiotic; Gut–brain axis; Autism; Biology; Prefrontal cortex; Medicine; Neuroscience; Biochemistry; Cognition; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009681139,0.0001461197,0.0001467184,0.00007173931,0.0005707759,0.00003380851,0.0005755603,0.00005023614,0.00001014431],"category_scores_gemma":[0.00004617999,0.00008540403,0.00008335859,0.000400122,0.0004198406,0.000006564182,0.0001493275,0.00011519,0.000001110088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006421102,"about_ca_system_score_gemma":0.0003864729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002820214,"about_ca_topic_score_gemma":0.0001554455,"domain_scores_codex":[0.9985461,0.0003553628,0.0002146035,0.0003937229,0.0001613936,0.0003288671],"domain_scores_gemma":[0.99949,0.00009067718,0.0001130908,0.0002547676,0.00002320638,0.00002826999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003234953,0.0001648898,0.0003473943,0.00000670272,0.00001527878,5.983609e-7,0.002734996,0.00503893,0.9876193,0.0008243209,0.003031792,0.0001834722],"study_design_scores_gemma":[0.003671362,0.01076536,0.06204035,0.00005253469,0.00005908701,0.0002087748,0.01676914,0.03326577,0.8498146,0.002699875,0.01938186,0.001271313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849285,0.0003618004,0.0000882431,0.01331802,0.00004191626,0.0006056609,0.0001317758,0.0000059289,0.0005181453],"genre_scores_gemma":[0.9958197,0.00003112398,0.0004535497,0.002119397,0.00001818165,0.00005973045,0.00002645624,0.000008278861,0.001463566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1378047,"threshold_uncertainty_score":0.4390005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02087473448979667,"score_gpt":0.2761163648500757,"score_spread":0.2552416303602791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}