{"id":"W4282947280","doi":"10.3390/brainsci12060781","title":"Selective Probiotic Treatment Positively Modulates the Microbiota–Gut–Brain Axis in the BTBR Mouse Model of Autism","year":2022,"lang":"en","type":"article","venue":"Brain Sciences","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Alberta Children's Hospital; Lallemand (Canada); University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Canadian Institutes of Health Research; University of Calgary; Cumming School of Medicine, University of Calgary; Alberta Children's Hospital Research Institute","keywords":"Gut flora; Probiotic; Gut–brain axis; Autism; Biology; Prefrontal cortex; Medicine; Neuroscience; Biochemistry; Cognition; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004240804,0.001453972,0.001114277,0.001861327,0.0005037567,0.0005028275,0.0004852356,0.001264777,0.002541146],"category_scores_gemma":[0.000270274,0.0004844635,0.0007874329,0.0003777353,0.0007703045,0.0005236985,0.000512076,0.002123346,0.00062915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000514973,"about_ca_system_score_gemma":0.0004533782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001693171,"about_ca_topic_score_gemma":0.003697644,"domain_scores_codex":[0.9993954,0.00008775407,0.00007375595,0.000165605,0.0001467666,0.0001306911],"domain_scores_gemma":[0.9995019,0.00002578233,0.0001650287,0.00003410129,0.00005344827,0.0002196777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001541776,0.0004867947,0.0004785262,0.00009704148,0.00001614376,0.0001181837,0.00006656162,0.00004395944,0.9952332,0.00004449506,0.0001086523,0.001764728],"study_design_scores_gemma":[0.0008632059,0.03509419,0.07405233,0.0002765982,0.0003846542,0.00169559,0.0008901969,0.00214531,0.8746287,0.0005179638,0.009335672,0.0001157575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924992,0.002097196,0.001635796,0.0004893622,0.0001150601,0.0001246094,0.001642171,0.0002415968,0.001155074],"genre_scores_gemma":[0.9764153,0.003486927,0.006373925,0.0004584331,0.00006100014,0.0007843999,0.002235837,0.0001580067,0.01002631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002541146,"threshold_uncertainty_score":0.008500993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02087473448979667,"score_gpt":0.2761163648500757,"score_spread":0.2552416303602791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}