{"id":"W4282961792","doi":"10.1158/1538-7445.am2022-5394","title":"Abstract 5394: Uterine leiomyosarcoma with homologous recombination deficiency is highly sensitive to polo-like kinase 4 inhibitor","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Biology; Homologous recombination; Molecular biology; Mitotic catastrophe; Apoptosis; Mitosis; Cell cycle; Cancer research; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007669602,0.0003117934,0.0002778383,0.0002462054,0.0001221607,0.0001431651,0.0001523901,0.0003294497,0.003126882],"category_scores_gemma":[0.0001225318,0.0001257383,0.0002537399,0.0001640676,0.0001720647,0.00009768699,0.0001264292,0.0004642697,0.0007316923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897355,"about_ca_system_score_gemma":0.0001202584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004189107,"about_ca_topic_score_gemma":0.0003259264,"domain_scores_codex":[0.9999044,0.00001127245,0.00001430236,0.00002410309,0.00002816317,0.00001779596],"domain_scores_gemma":[0.9999101,0.00002015274,0.0000315933,0.00001016867,0.000006978469,0.00002097501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001637263,0.0000383789,0.0008906444,0.00004860542,0.000012037,0.001215386,0.0000114882,0.00006964988,0.9954543,0.00005978592,0.0002557136,0.00178025],"study_design_scores_gemma":[0.00004748703,0.0007897394,0.02472727,0.00001345338,0.00005015248,0.01149515,0.00005604419,0.001121423,0.9567321,0.0001136557,0.004839547,0.0000139003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992709,0.001582987,0.001937125,0.000214965,0.00006874654,0.00003649361,0.001444273,0.0002050436,0.001801293],"genre_scores_gemma":[0.9925461,0.0006734941,0.0008767608,0.00008219922,0.00001104139,0.00005768757,0.001884144,0.00002527534,0.003843338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003126882,"threshold_uncertainty_score":0.0104605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0255860066364757,"score_gpt":0.336115734614655,"score_spread":0.3105297279781793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}