{"id":"W4282961847","doi":"10.1158/1538-7445.am2022-60","title":"Abstract 60: Functional mapping reveals widespread remodelling and unrecognized pathway dependencies in recurrent glioblastoma","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"","keywords":"PTEN; Glioblastoma; Cancer; Cancer research; Medicine; Biology; Signal transduction; Internal medicine; Genetics; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071745,0.000233344,0.0002089576,0.000501267,0.0001815186,0.000324662,0.0002396782,0.0002895057,0.003329237],"category_scores_gemma":[0.000133274,0.0001445835,0.0002445838,0.0002215957,0.0002259847,0.0001709057,0.0003261828,0.0003154065,0.0006403194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000330716,"about_ca_system_score_gemma":0.0001971469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001377087,"about_ca_topic_score_gemma":0.001772732,"domain_scores_codex":[0.9998988,0.000006858181,0.000006051562,0.00002508231,0.00003890274,0.00002431729],"domain_scores_gemma":[0.999904,0.00001157406,0.00002897978,0.00001451339,0.00001685508,0.00002406369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006803617,0.00001161881,0.000785618,0.00001964902,0.000005348331,0.0002013474,0.00001276877,0.000118497,0.9946617,0.0001227655,0.0002042903,0.003788322],"study_design_scores_gemma":[0.0000237914,0.0004123574,0.097142,0.00001478211,0.00005103334,0.00469027,0.0001211643,0.003358256,0.88713,0.0004938042,0.006539167,0.0000233087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867294,0.001088613,0.007237223,0.0002697198,0.00003245814,0.0000222339,0.0009941889,0.0003533215,0.003272786],"genre_scores_gemma":[0.9918067,0.0005198612,0.003006939,0.00008740051,0.000007680407,0.00002047735,0.0008522627,0.00004689665,0.00365178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003329237,"threshold_uncertainty_score":0.01113743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.15311181591809,"score_gpt":0.3728429656389958,"score_spread":0.2197311497209058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}