{"id":"W4282961898","doi":"10.1158/1538-7445.am2022-1839","title":"Abstract 1839: Nelfinavir induced-cytotoxicity towards high-grade serous ovarian cancer cells involves induction of the unfolded protein response, modulation of protein synthesis, DNA damage, lysosomal impairment, and potentiation of toxicity caused by proteasome inhibition","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Unfolded protein response; Nelfinavir; Cancer research; Pharmacology; Medicine; Biology; Chemistry; Endoplasmic reticulum; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008621283,0.0002696226,0.000277137,0.0001225412,0.0001371828,0.0001880612,0.0001091909,0.000239688,0.002097994],"category_scores_gemma":[0.00008868401,0.00006801044,0.0002126469,0.0001524002,0.0001341515,0.0001156594,0.0001184481,0.0003690318,0.0003951092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001457907,"about_ca_system_score_gemma":0.0001277053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003538258,"about_ca_topic_score_gemma":0.0003868692,"domain_scores_codex":[0.9998983,0.00001999201,0.00001300024,0.00001624003,0.00003011659,0.0000222532],"domain_scores_gemma":[0.9999547,0.00001204579,0.000008597244,0.000008305515,0.000007472629,0.0000088803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003072781,0.00007237837,0.0003278666,0.00007109097,0.000006512525,0.00007573702,0.0000161596,0.00004301863,0.996985,0.00004533658,0.00008358928,0.001966064],"study_design_scores_gemma":[0.00003617372,0.001013499,0.007496592,0.000007835533,0.00001092153,0.0005375821,0.00002310074,0.0004305536,0.9874773,0.00002596585,0.002937672,0.000002793081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945852,0.001835941,0.0009080269,0.00007238417,0.00005631783,0.00003701925,0.0007508983,0.0000428396,0.001711346],"genre_scores_gemma":[0.9944173,0.0007231276,0.0009096533,0.00005069472,0.00001342792,0.00003981222,0.001455003,0.000008493456,0.002382475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002097994,"threshold_uncertainty_score":0.007018507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04260717220798169,"score_gpt":0.316364421647377,"score_spread":0.2737572494393953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}