{"id":"W4282962127","doi":"10.1158/1538-7445.am2022-572","title":"Abstract 572: Pre-clinical evaluation of Claudin 18.2 TAC T cells for the treatment of gastric cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences","funders":"","keywords":"Cancer research; Cancer; Claudin; Tight junction; In vivo; Immunotherapy; Cytotoxic T cell; Medicine; Cancer cell; Immunology; In vitro; Chemistry; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004315941,0.0005056922,0.0005515305,0.0002688848,0.0001956836,0.0005395469,0.0003570217,0.0005509473,0.0032473],"category_scores_gemma":[0.0002335497,0.0001343832,0.0003612794,0.0001868921,0.0002725436,0.0002716592,0.0001651733,0.001283447,0.0005856401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003524479,"about_ca_system_score_gemma":0.0005323213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005754881,"about_ca_topic_score_gemma":0.000674247,"domain_scores_codex":[0.9998671,0.00003524864,0.000009645949,0.00001733966,0.00003113132,0.00003960341],"domain_scores_gemma":[0.9998577,0.00001972478,0.00001900651,0.00001167287,0.00002500433,0.00006688124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03175852,0.0209676,0.002364706,0.0009347228,0.000213782,0.0006807942,0.0002339601,0.001334729,0.8599783,0.0004319191,0.003046758,0.07805412],"study_design_scores_gemma":[0.01927913,0.4704127,0.01297457,0.00007917779,0.0005611439,0.001356076,0.0001794861,0.002670302,0.4715706,0.0001436502,0.02074367,0.00002946187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933855,0.002411394,0.0007488007,0.0002338186,0.0001094384,0.0005459523,0.000327958,0.00007137958,0.002165814],"genre_scores_gemma":[0.9929528,0.001592991,0.001021893,0.000223103,0.00007385396,0.0004160048,0.0009278402,0.00002109973,0.002770476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0032473,"threshold_uncertainty_score":0.01086324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3995313886288464,"score_gpt":0.5792230089990879,"score_spread":0.1796916203702414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}