{"id":"W4282963647","doi":"10.1158/1538-7445.am2022-4133","title":"Abstract 4133: High prevalence and heterogeneity of emergence of <i>BRCA</i> reversion mutations at progression on niraparib treatment in <i>BRCA</i>-mutant metastatic castration-resistant prostate cancer (mCRPC) patients","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Reversion; Frameshift mutation; Prostate cancer; Medicine; Missense mutation; Cancer research; Mutation; Cancer; Nonsense mutation; Allele; Oncology; Internal medicine; Biology; Genetics; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003882587,0.0001329755,0.0002886871,0.0006166532,0.0002173423,0.0004449827,0.0002340153,0.0003367407,0.001472661],"category_scores_gemma":[0.001049137,0.0001267313,0.0001925258,0.0005006935,0.0002369696,0.0001887584,0.000208757,0.0002806949,0.0002771602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001464645,"about_ca_system_score_gemma":0.0001121804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006431797,"about_ca_topic_score_gemma":0.0007965101,"domain_scores_codex":[0.9995732,0.0001203736,0.00004244479,0.0001406183,0.00007608224,0.00004735312],"domain_scores_gemma":[0.9992782,0.0002047724,0.0003058686,0.000070558,0.00004457002,0.00009594121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000588824,0.00004003012,0.9843661,0.00002020162,0.00005473995,0.0004937283,0.0001302221,0.00006432681,0.006585197,0.00003925299,0.0001912488,0.007426123],"study_design_scores_gemma":[0.00002432911,0.0002263851,0.9961305,0.000004324575,0.00002299696,0.002371361,0.00009959251,0.0002091968,0.0005398658,0.00003435168,0.0003315757,0.000005467202],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995316,0.0001355894,0.0000320836,0.0000175471,0.000001214434,0.000004275958,0.00008798762,0.000003107751,0.0001866085],"genre_scores_gemma":[0.999768,0.00002693372,0.00002324098,0.00001945089,0.000003951534,0.000002347614,0.000114818,0.000001596225,0.00003979187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001472661,"threshold_uncertainty_score":0.004926503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08300330439989648,"score_gpt":0.4233405694843785,"score_spread":0.340337265084482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}