{"id":"W4282963864","doi":"10.1093/jac/dkac161","title":"Molecular mechanisms of acquired antifungal drug resistance in principal fungal pathogens and EUCAST guidance for their laboratory detection and clinical implications","year":2022,"lang":"en","type":"review","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Center, University of Rochester; National Institutes of Health; Dr. Falk Pharma; Idorsia Pharmaceuticals; Wockhardt; TenNor Therapeutics; Astellas Foundation for Research on Metabolic Disorders; Radboud Universitair Medisch Centrum; Basilea Pharmaceutica; Astellas Pharma; North Bristol NHS Trust; University of Queensland; Shionogi; Meiji Seika Pharma; European Society of Clinical Microbiology and Infectious Diseases; Roivant Sciences; National University of Singapore; Nabriva Therapeutics; Pfizer; Melinta Therapeutics; Entasis Therapeutics; U.S. Food and Drug Administration; Amplyx; Achaogen; Albany College of Pharmacy and Health Sciences; GenePOC; University of Texas Southwestern Medical Center; Medicines Company; University of North Texas; Boston Pharmaceuticals; Novartis; Harvard University; F. Hoffmann-La Roche; Wayne State University; Pfizer Healthcare Ireland; Beth Israel Deaconess Medical Center; Bayer; Gilead Sciences; Insmed; Medpace; GlaxoSmithKline; Allergan; Cidara Therapeutics; University of Southern California; Tufts Medical Center","keywords":"Antifungal; Drug resistance; Microbiology; Antifungal drugs; Biology; Antifungal drug; Drug; Medicine; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002045134,0.0003714031,0.002156865,0.0002682083,0.0001074104,0.00002612986,0.0002102299,0.0002945947,0.00001698109],"category_scores_gemma":[0.0002669832,0.0003070616,0.0006899132,0.0004069461,0.0002283724,0.0001019581,0.00005509819,0.0004529454,1.866673e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001704926,"about_ca_system_score_gemma":0.0007363003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002287823,"about_ca_topic_score_gemma":0.00004640414,"domain_scores_codex":[0.9968633,0.0003232942,0.001835138,0.0004689633,0.0002277192,0.0002815539],"domain_scores_gemma":[0.997193,0.0003767769,0.001564279,0.0003907246,0.0003276456,0.000147615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008128454,0.003198636,0.00488466,0.04348993,0.002325502,0.0002878795,0.0009183767,0.000001465164,0.3314024,0.0008464078,0.001733465,0.6027828],"study_design_scores_gemma":[0.01019831,0.001732829,0.01136591,0.01782397,0.002276785,0.0008254552,0.0002716451,0.00001771892,0.02302503,0.0007646615,0.9304123,0.001285391],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1202126,0.8742201,0.002795983,0.0004522491,0.0003026998,0.001540002,0.0004298961,0.00001467803,0.00003173234],"genre_scores_gemma":[0.04013661,0.9552344,0.004060781,0.0002556737,0.0001519174,0.00001619051,0.00001570287,0.00007602647,0.000052668],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9286789,"threshold_uncertainty_score":0.9999381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03514572353834217,"score_gpt":0.3423288399970542,"score_spread":0.307183116458712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}