{"id":"W4282965232","doi":"10.1158/1538-7445.am2022-ct011","title":"Abstract CT011: NeoCOAST: open-label, randomized, phase 2, multidrug platform study of neoadjuvant durvalumab alone or combined with novel agents in patients (pts) with resectable, early-stage non-small-cell lung cancer (NSCLC)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"","keywords":"Medicine; Durvalumab; Tolerability; Clinical endpoint; Neoadjuvant therapy; Internal medicine; Lung cancer; Gastroenterology; Oncology; Cancer; Lymph node; Surgery; Randomized controlled trial; Immunotherapy; Breast cancer; Adverse effect; Pembrolizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001474714,0.002515077,0.002275035,0.000507289,0.0005237192,0.001396725,0.001394608,0.001781712,0.01015373],"category_scores_gemma":[0.001147844,0.000905787,0.00116302,0.0005526743,0.001503524,0.001550154,0.0005837164,0.003690675,0.0020927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001387942,"about_ca_system_score_gemma":0.00206152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00135454,"about_ca_topic_score_gemma":0.005183931,"domain_scores_codex":[0.9995465,0.0002321091,0.00002202448,0.00007953376,0.00003892153,0.00008082862],"domain_scores_gemma":[0.999213,0.0001148895,0.0001561364,0.00005621526,0.00004407243,0.0004156507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9565128,0.01823796,0.001234789,0.0003848931,0.0004552161,0.00006863198,0.00007599238,0.0004724267,0.00797506,0.0001549009,0.00188919,0.01253806],"study_design_scores_gemma":[0.9099753,0.08708283,0.001307831,0.00001334738,0.0001296272,0.00004492806,0.0000195131,0.0002664052,0.0004722415,0.00007738902,0.0005981372,0.00001244391],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983895,0.00141838,0.0006225972,0.0009316733,0.0003779721,0.006459014,0.002838463,0.0001512982,0.003305533],"genre_scores_gemma":[0.972847,0.001629758,0.002057422,0.001797599,0.0004641558,0.007904854,0.004328298,0.0000587974,0.008912186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01015373,"threshold_uncertainty_score":0.03396767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1018290900506735,"score_gpt":0.4069291801461712,"score_spread":0.3051000900954977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}