{"id":"W4282966748","doi":"10.1158/1538-7445.am2022-ct503","title":"Abstract CT503: A phase I/Ib study of the safety and preliminary efficacy of NZV930 alone and in combination with spartalizumab and/or taminadenant in patients (pts) with advanced malignancies","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Oncology; Cancer; Pharmacodynamics; Pharmacokinetics; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009332929,0.001306025,0.001225534,0.0004161698,0.0004123816,0.0009559924,0.0009209211,0.0009941502,0.006452552],"category_scores_gemma":[0.0006798843,0.0004099282,0.001067926,0.0005388383,0.0009911172,0.0006994422,0.000289403,0.002953535,0.001401519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001430951,"about_ca_system_score_gemma":0.00188014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003267746,"about_ca_topic_score_gemma":0.007033792,"domain_scores_codex":[0.9997274,0.0001214009,0.00001675604,0.00004641003,0.00002950181,0.00005834628],"domain_scores_gemma":[0.999626,0.00005689215,0.00007139434,0.00003574535,0.00002589554,0.0001840846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6164061,0.06023322,0.01103564,0.0009946382,0.001102843,0.0005957162,0.0004635807,0.004180132,0.1828604,0.000598145,0.008762417,0.1127672],"study_design_scores_gemma":[0.3145024,0.6475028,0.01801092,0.00005612676,0.0005820104,0.0006308,0.0001043067,0.001290889,0.01195156,0.0001929917,0.005136593,0.00003861194],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909877,0.001442384,0.0004745838,0.0003903128,0.00007983566,0.001577651,0.001998202,0.000129095,0.002920173],"genre_scores_gemma":[0.9886535,0.001242838,0.0009802544,0.0004617544,0.0001009134,0.001058037,0.004044622,0.00003430126,0.003423906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006452552,"threshold_uncertainty_score":0.02158594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287567440689732,"score_gpt":0.3292909989816322,"score_spread":0.3064153245747349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}