{"id":"W4282967516","doi":"10.1158/1538-7445.am2022-1580","title":"Abstract 1580: Cancer cells promote phenotypic alterations in adjacent hepatocytes to facilitate vessel co-option in colorectal cancer liver metastasis","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Cancer cell; Metastasis; Downregulation and upregulation; Cancer research; Cancer; Colorectal cancer; Epithelial–mesenchymal transition; Liver cancer; Motility; Gene knockdown; Biology; Apoptosis; Cell biology; Chemistry; Medicine; Internal medicine; Hepatocellular carcinoma; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001224282,0.0002279796,0.0002694545,0.0002873561,0.0002379448,0.0003422781,0.0001404205,0.0004267697,0.006587967],"category_scores_gemma":[0.00008686284,0.0001373298,0.0002850093,0.0002467812,0.0002148619,0.0002219763,0.0002700452,0.0007147248,0.001616387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002847478,"about_ca_system_score_gemma":0.0002446379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004452254,"about_ca_topic_score_gemma":0.0006258595,"domain_scores_codex":[0.9998474,0.00002008563,0.00001305014,0.0000276534,0.00005966484,0.00003211897],"domain_scores_gemma":[0.9999493,0.000006339787,0.0000110013,0.000005448294,0.00001352712,0.00001443815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002189377,0.0000767058,0.0005264474,0.0002094345,0.00001199048,0.0002505293,0.0000383066,0.00008656319,0.991367,0.0004295848,0.001000829,0.005783722],"study_design_scores_gemma":[0.00006380899,0.0006578904,0.01448476,0.00002720246,0.00003774304,0.001492499,0.0001197951,0.0009872518,0.9566305,0.0001891,0.02529724,0.00001210692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649759,0.01279994,0.006669712,0.001380765,0.0004591461,0.00009202884,0.00117318,0.0005007133,0.01194861],"genre_scores_gemma":[0.9735807,0.002862103,0.002603371,0.0002638072,0.00006103363,0.00007527323,0.0008645082,0.00003567741,0.01965346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006587967,"threshold_uncertainty_score":0.02203888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07549367872509552,"score_gpt":0.3731491279069126,"score_spread":0.2976554491818171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}