{"id":"W4282968704","doi":"10.1038/s41598-022-14116-x","title":"Predisposition of HLA-DRB1*04:01/*15 heterozygous genotypes to Japanese mixed connective tissue disease","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pfizer Japan; Teijin Pharma; Astellas Foundation for Research on Metabolic Disorders; Merck Sharp and Dohme; Eisai; Pfizer; Japan Research Foundation for Clinical Pharmacology; Abbott Japan; Japan Society for the Promotion of Science; Mitsui Sumitomo Insurance Welfare Foundation; Eisai Canada; Nakatomi Foundation; Daiwa Securities Health Foundation; Bristol-Myers Squibb; Takeda Science Foundation; Astellas Pharma; Chugai Pharmaceutical; Mitsubishi Tanabe Pharma Corporation; Astellas Pharma US; Japan Agency for Medical Research and Development","keywords":"Mixed connective tissue disease; Odds ratio; Genotype; Medicine; HLA-DRB1; Allele; Internal medicine; Genotyping; Immunology; Haplotype; Genetic predisposition; Human leukocyte antigen; Gastroenterology; Disease; Biology; Genetics; Antigen","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003715296,0.0004032666,0.0003246206,0.000777386,0.0004601885,0.0003773023,0.0002163329,0.0003492994,0.005045529],"category_scores_gemma":[0.001054775,0.0002635166,0.0002668587,0.0005886817,0.0003215095,0.0001680642,0.0002934654,0.0003579944,0.0002858197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001188022,"about_ca_system_score_gemma":0.0001194102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003559547,"about_ca_topic_score_gemma":0.002086394,"domain_scores_codex":[0.9996847,0.000092946,0.00003582472,0.00008986428,0.00003904809,0.00005760975],"domain_scores_gemma":[0.9994886,0.0000870827,0.0001948642,0.00003903027,0.00005145102,0.0001390267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004026109,0.00007940658,0.9829412,0.00004762957,0.0001427982,0.004118783,0.0003928492,0.00004807497,0.0083187,0.0001192205,0.0003206672,0.003067984],"study_design_scores_gemma":[0.00003497942,0.0002304895,0.9864261,0.00002537409,0.0001735154,0.01086956,0.0005185187,0.0003216728,0.0005145652,0.0001268085,0.0007448068,0.00001352256],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989869,0.0003188612,0.0001224594,0.00003645674,0.00001199229,0.000006437606,0.00004090156,0.000004287826,0.0004716412],"genre_scores_gemma":[0.9995692,0.00008600552,0.00007488055,0.00002114747,0.0000112195,0.000003418198,0.00004181577,0.000001972902,0.0001904226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005045529,"threshold_uncertainty_score":0.01687896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170321464342973,"score_gpt":0.2929385402854689,"score_spread":0.2759063938511716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}