{"id":"W4282968918","doi":"10.1158/1538-7445.am2022-5221","title":"Abstract 5221: The first-in-class ERK inhibitor ulixertinib (BVD-523) shows activity in MAPK-driven pediatric low-grade glioma models as single agent and in combination with MEK inhibitors or senolytics","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Phenomenome Discoveries (Canada)","funders":"","keywords":"In vivo; MAPK/ERK pathway; Cancer research; MEK inhibitor; Glioma; Medicine; Pharmacology; Biology; Kinase; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001153914,0.0005889202,0.0004111775,0.0002891975,0.000124522,0.0002390731,0.0002283677,0.0003033772,0.002034634],"category_scores_gemma":[0.0000494756,0.0001068447,0.0003231021,0.0002107653,0.0001264349,0.000187707,0.0001050319,0.000627525,0.0005469207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003218051,"about_ca_system_score_gemma":0.0003382128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001318893,"about_ca_topic_score_gemma":0.002036681,"domain_scores_codex":[0.9999102,0.0000118012,0.000008680258,0.00001651956,0.00002055149,0.00003218127],"domain_scores_gemma":[0.999966,0.000003564021,0.000008415238,0.000003589152,0.000004162028,0.0000142415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001781827,0.0004970056,0.0003130692,0.0001649988,0.00003200411,0.00009934237,0.00001415714,0.0004294401,0.9863005,0.00009674532,0.0008951171,0.00937576],"study_design_scores_gemma":[0.0002385056,0.004010799,0.003988801,0.00001002718,0.00006810693,0.0004609831,0.00001593121,0.0009040062,0.986445,0.00002272782,0.003825314,0.00000978735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892094,0.003474375,0.001043728,0.0001518076,0.00006092853,0.00007302385,0.002425412,0.0003071228,0.003254156],"genre_scores_gemma":[0.9896107,0.002534959,0.00131745,0.00005803019,0.00001144676,0.00007247496,0.003277629,0.00002814097,0.003089234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002034634,"threshold_uncertainty_score":0.006806552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07356030715229593,"score_gpt":0.3468177770872878,"score_spread":0.2732574699349918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}