{"id":"W4282969370","doi":"10.1158/1538-7445.am2022-ct247","title":"Abstract CT247: A phase I/II trial investigating safety and efficacy of autologous TAC T cells targeting HER2 in relapsed or refractory solid tumors (TACTIC-2)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Chimeric antigen receptor; Leukapheresis; Cancer research; T cell; Immunohistochemistry; Breast cancer; Antigen; Cancer; T-cell receptor; Immunotherapy; Oncology; Immunology; Internal medicine; Immune system; Biology; CD34; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001025871,0.001502785,0.001402928,0.0003779203,0.0004015469,0.001026827,0.0009523351,0.001585258,0.006000051],"category_scores_gemma":[0.0005759925,0.0003956188,0.000895285,0.0004482442,0.0008338344,0.0006705613,0.0002972477,0.003400605,0.001798338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008941687,"about_ca_system_score_gemma":0.00155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000764649,"about_ca_topic_score_gemma":0.001643109,"domain_scores_codex":[0.9996902,0.0001393532,0.00001660625,0.00005265454,0.00003191872,0.00006930477],"domain_scores_gemma":[0.9995307,0.00004791063,0.00007301885,0.00003497444,0.00002935424,0.0002841535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7041024,0.06239117,0.006604589,0.00187719,0.001770514,0.001001064,0.0002617777,0.003844803,0.1045826,0.0005951831,0.01387254,0.09909622],"study_design_scores_gemma":[0.5068506,0.4725119,0.005439637,0.00007230559,0.000499486,0.0006978383,0.00005391301,0.001111533,0.0078243,0.0002466302,0.004659187,0.00003254856],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836262,0.003381418,0.0007675972,0.0007871375,0.0001870179,0.004234139,0.003026742,0.0002545965,0.003735133],"genre_scores_gemma":[0.9780959,0.00214232,0.001549317,0.001282795,0.0002177529,0.004781959,0.005788662,0.00004980174,0.006091403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006000051,"threshold_uncertainty_score":0.02007216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1010880607560795,"score_gpt":0.4461038510280492,"score_spread":0.3450157902719697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}