{"id":"W4282969511","doi":"10.1128/aac.00439-22","title":"Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells","year":2022,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Hospital for Sick Children; University of Toronto","funders":"Horizon 2020 Framework Programme; Hospital for Sick Children; European Commission; Government of Ontario; George Mason University; Canadian Institute for Advanced Research; Fast Grants","keywords":"Bafilomycin; Endosome; Proteases; Viral entry; Biology; Cell biology; Lipid bilayer fusion; Transmembrane protein; TMPRSS2; Virology; Biochemistry; Virus; Viral replication; Intracellular; Enzyme; Receptor; Autophagy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001227861,0.0003832134,0.0006239453,0.0002081231,0.0001614188,0.0003306432,0.0002126058,0.0002897175,0.0008879869],"category_scores_gemma":[0.0001440376,0.0001312484,0.0003178759,0.00020725,0.0001487433,0.0001553942,0.0001351482,0.0004942712,0.0003755761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464438,"about_ca_system_score_gemma":0.0002759132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006983162,"about_ca_topic_score_gemma":0.001217639,"domain_scores_codex":[0.9998354,0.00002321685,0.0000187434,0.0000253936,0.00005435813,0.00004291114],"domain_scores_gemma":[0.9999031,0.0000260307,0.00001990061,0.00001317093,0.00001484986,0.0000229442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001433091,0.0001042023,0.0001019962,0.0000267601,0.00001197327,0.00002681577,0.000006703999,0.0001384697,0.9980595,0.00004026437,0.00006410011,0.001275913],"study_design_scores_gemma":[0.00004257766,0.0007611568,0.002925882,0.000004247349,0.0000229965,0.0001639091,0.00001245725,0.001315091,0.9920852,0.00001689866,0.002643905,0.000005704026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936408,0.00190813,0.00210105,0.0001148208,0.00003714554,0.0000711962,0.0005188909,0.0001235155,0.001484463],"genre_scores_gemma":[0.9947655,0.001025492,0.001433984,0.00005624483,0.00001379383,0.00007625385,0.0008538931,0.00001897924,0.001755872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008879869,"threshold_uncertainty_score":0.002970636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0452033015836248,"score_gpt":0.3269386519126324,"score_spread":0.2817353503290076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}