{"id":"W4282970098","doi":"10.1158/1538-7445.am2022-1759","title":"Abstract 1759: PRO1160, a novel CD70-directed antibody-drug conjugate, demonstrates robust anti-tumor activity in mouse models of renal cell carcinoma and non-Hodgkin lymphoma","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Profound Medical (Canada)","funders":"","keywords":"In vivo; Antibody-drug conjugate; Cancer research; Antibody; Lymphoma; Cancer; Monoclonal antibody; Conjugate; Chemistry; Medicine; Biology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000187928,0.000726237,0.0003011872,0.0006194952,0.000136007,0.0002473916,0.0002944303,0.0005498774,0.003465428],"category_scores_gemma":[0.00007211701,0.0001592313,0.0002354818,0.0002433535,0.0002046934,0.0003253521,0.0001376356,0.0006861577,0.0009317438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004685016,"about_ca_system_score_gemma":0.0002754277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001083774,"about_ca_topic_score_gemma":0.001057904,"domain_scores_codex":[0.9998522,0.00001840507,0.00001348033,0.00003032613,0.00004908823,0.00003650419],"domain_scores_gemma":[0.9999429,0.000004362887,0.00001782792,0.0000036314,0.000008843617,0.00002239744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003750568,0.0001784592,0.0001010809,0.00007922597,0.00001073156,0.00008335171,0.00001045762,0.000147042,0.9928071,0.0002029649,0.0005173499,0.005486996],"study_design_scores_gemma":[0.00006816502,0.001422209,0.001074426,0.000005894953,0.00001837345,0.0002802522,0.000005396682,0.0005529287,0.9911931,0.00002556864,0.005349227,0.000004460761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643895,0.007978711,0.01177252,0.0007935366,0.0004045973,0.0003047097,0.0022137,0.001069883,0.0110729],"genre_scores_gemma":[0.9568768,0.00397734,0.006944974,0.0002258367,0.00007224813,0.000156479,0.00322362,0.000068929,0.02845371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003465428,"threshold_uncertainty_score":0.01159298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06835948229947149,"score_gpt":0.3566056716250506,"score_spread":0.2882461893255792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}