{"id":"W4282970131","doi":"10.1158/1538-7445.am2022-1853","title":"Abstract 1853: TH1902, a SORT1 docetaxel peptide-drug conjugate, inhibits tumor growth of human cancer stem-like cells (CD133+) from both triple-negative breast cancers and ovarian cancers","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Theratechnologies (Canada)","funders":"","keywords":"Docetaxel; Homeobox protein NANOG; SOX2; Cancer stem cell; Cancer research; CD44; Biology; Triple-negative breast cancer; Population; Stem cell; Cancer; Ovarian cancer; Cancer cell; Breast cancer; Internal medicine; Cell; Medicine; Induced pluripotent stem cell; Cell biology; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009498026,0.0003723865,0.0002653902,0.0002099547,0.00009662665,0.0001942085,0.00014015,0.0002692221,0.00223139],"category_scores_gemma":[0.00005840316,0.0001202973,0.0001919249,0.0001685296,0.0001119988,0.0001142827,0.00008740684,0.0004079026,0.0004403325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002413195,"about_ca_system_score_gemma":0.000274535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001162238,"about_ca_topic_score_gemma":0.001510642,"domain_scores_codex":[0.999936,0.00001236907,0.000006682052,0.00001107411,0.00001757055,0.00001639818],"domain_scores_gemma":[0.9999682,0.00000673033,0.000005780472,0.000003461326,0.000004394914,0.00001150966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006327932,0.0002238452,0.0002203215,0.00007754261,0.00001698736,0.00005714254,0.00002084994,0.00016148,0.9937356,0.0000901547,0.0003464476,0.004416962],"study_design_scores_gemma":[0.0001937205,0.002610594,0.002313617,0.000004354798,0.00002850112,0.0002799887,0.00001327155,0.0008716963,0.9900603,0.00001168954,0.003607563,0.000004720192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949629,0.001147581,0.0008179545,0.0000904515,0.00004764637,0.00007705315,0.0006141777,0.00008480317,0.002157419],"genre_scores_gemma":[0.9922141,0.0008761165,0.001330492,0.00006215823,0.00001759176,0.00004649163,0.001554838,0.00002046235,0.00387764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00223139,"threshold_uncertainty_score":0.007464767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03430642932677555,"score_gpt":0.3271289534071801,"score_spread":0.2928225240804045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}