{"id":"W4282970563","doi":"10.1158/1538-7445.am2022-5650","title":"Abstract 5650: RP-6306, a novel PKMYT1 inhibitor, demonstrates synthetic lethality as monotherapy and in combination with gemcitabine in <i>CCNE1</i> amplified cancer cells","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada)","funders":"","keywords":"Cyclin-dependent kinase 1; Cyclin E1; Wee1; Cancer research; Genome instability; Cell cycle; Biology; Molecular biology; Mitosis; Phosphorylation; Cyclin-dependent kinase 2; Cell biology; Chemistry; Cancer; Protein kinase A; DNA damage; Biochemistry; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001073784,0.0004700034,0.0005537866,0.0002756066,0.0001205456,0.0001961361,0.0002812771,0.0003522925,0.002511628],"category_scores_gemma":[0.0001085492,0.0001100412,0.0002456895,0.0001953841,0.0001487185,0.0001294219,0.0001419249,0.000622082,0.0006910593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001698376,"about_ca_system_score_gemma":0.0002196631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006617577,"about_ca_topic_score_gemma":0.0008319074,"domain_scores_codex":[0.9999093,0.0000188676,0.00001351161,0.00001570238,0.00002151372,0.00002125916],"domain_scores_gemma":[0.999917,0.00001842287,0.00001615744,0.00001103237,0.000007452847,0.0000298435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001623938,0.0004624655,0.0003561685,0.0001586154,0.00003566519,0.0002427528,0.00002590089,0.0004672788,0.9859776,0.0001196581,0.0007198611,0.009810125],"study_design_scores_gemma":[0.0003245346,0.00797847,0.004909024,0.00001582104,0.00005596446,0.0009390993,0.00001737973,0.001227731,0.9805019,0.00003203671,0.003985624,0.00001230789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897876,0.003455032,0.00087052,0.0001478942,0.0000862768,0.00007675081,0.001059305,0.0002485778,0.004267954],"genre_scores_gemma":[0.9923117,0.001499312,0.001290813,0.00008226065,0.00001778239,0.00006522724,0.001776165,0.00002829188,0.002928419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002511628,"threshold_uncertainty_score":0.008402228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04949660986831002,"score_gpt":0.3582929398842499,"score_spread":0.3087963300159399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}