{"id":"W4282970713","doi":"10.1084/jem.20211860","title":"Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT","year":2022,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Glycomics Network; Canadian MPS Society for Mucopolysaccharide and Related Diseases; Mizutani Foundation for Glycoscience; Canadian Institutes of Health Research; Sanfilippo Children's Foundation; Wellcome Trust","keywords":"Glucosamine; Mucopolysaccharidosis; Pathology; Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001611361,0.0002209717,0.0006574075,0.0005294948,0.0002427703,0.000008031803,0.0004922997,0.00005392604,0.002925517],"category_scores_gemma":[0.0002693358,0.0001414887,0.0001198206,0.0005984797,0.0003807767,0.0001209112,0.0003062892,0.0009980934,0.000005580197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006192153,"about_ca_system_score_gemma":0.0001315776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000217952,"about_ca_topic_score_gemma":0.00000605518,"domain_scores_codex":[0.9968839,0.0005069022,0.0007960449,0.0001974046,0.001169926,0.0004458206],"domain_scores_gemma":[0.9987104,0.0002307215,0.0003632573,0.0003680824,0.00009883595,0.000228683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002386999,0.0007946964,0.001671901,0.00001807297,0.00007439821,0.001234906,0.008924238,0.00004172889,0.9803774,0.00003655952,0.002976103,0.001463028],"study_design_scores_gemma":[0.03002619,0.01320145,0.00324592,0.0003844207,0.0002479935,0.01295708,0.1027398,0.000817898,0.8321007,0.000167493,0.003708474,0.0004025901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710737,0.02065926,0.00004311439,0.006695421,0.0003951052,0.0003387798,0.000003756184,0.00001618346,0.0007746807],"genre_scores_gemma":[0.9970024,0.0003502892,0.0001354046,0.001418443,0.0003222368,0.00002981382,0.000008866624,0.00004276451,0.0006897791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1482766,"threshold_uncertainty_score":0.997986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03674157621450594,"score_gpt":0.3396111526834962,"score_spread":0.3028695764689903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}