{"id":"W4282971574","doi":"10.3389/ftox.2022.895667","title":"Safety and Toxicity Implications of Multifunctional Drug Delivery Nanocarriers on Reproductive Systems In Vitro and In Vivo","year":2022,"lang":"en","type":"review","venue":"Frontiers in Toxicology","topic":"Nanoparticles: synthesis and applications","field":"Materials Science","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Nanotoxicology; Nanomedicine; Nanocarriers; Nanotechnology; Context (archaeology); Drug delivery; Cosmetics; Engineering ethics; Medicine; Engineering; Nanoparticle; Biology; Materials science; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001256121,0.0002895816,0.0006170439,0.00106375,0.0002740287,0.0006051678,0.0002719839,0.0005455774,0.001231028],"category_scores_gemma":[0.001703812,0.0001568179,0.0008162172,0.0007569924,0.0004135382,0.0005384607,0.0003860767,0.0003587775,0.000182395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004639405,"about_ca_system_score_gemma":0.0006524359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001289812,"about_ca_topic_score_gemma":0.001665811,"domain_scores_codex":[0.9992012,0.0002662384,0.0001171337,0.0001450455,0.0002086026,0.00006183719],"domain_scores_gemma":[0.9991305,0.0004921317,0.0001850785,0.00003110412,0.0001355359,0.00002559273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002377842,0.000211658,0.008190938,0.03140178,0.0008185866,0.001922765,0.0006203081,0.00198305,0.6196599,0.003485812,0.002983782,0.3263436],"study_design_scores_gemma":[0.000192251,0.006914757,0.03537216,0.004976507,0.002518298,0.005691345,0.0009477658,0.001934835,0.7627655,0.003398046,0.175146,0.0001426159],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1144564,0.8716946,0.003440863,0.000997539,0.0002680032,0.0001338819,0.001074436,0.00003788608,0.007896427],"genre_scores_gemma":[0.4888973,0.5022827,0.003934667,0.001164488,0.0001457525,0.0001928115,0.0009413296,0.00002210791,0.002419037],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001289812,"threshold_uncertainty_score":0.006643116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02521579357599844,"score_gpt":0.2743324045466041,"score_spread":0.2491166109706057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}