{"id":"W4282971845","doi":"10.1158/1538-7445.am2022-1062","title":"Abstract 1062: Antiproliferative activity of EC359, an inhibitor of leukemia inhibitory factor receptor (LIF-R), singly and in combination with chemotherapy drugs against pancreatic cancer cell lines","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; London Health Sciences Centre","funders":"","keywords":"Gemcitabine; Pancreatic cancer; Docetaxel; Irinotecan; Cancer research; Cancer; Chemotherapy; Medicine; Internal medicine; Cancer cell; Oncology; Chemistry; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001614372,0.0004563157,0.000458117,0.0003827614,0.0001663679,0.0002818239,0.000243174,0.0003608189,0.002520606],"category_scores_gemma":[0.0001450854,0.0001415202,0.0004153655,0.0004045576,0.0001370081,0.0001620871,0.0001441424,0.0007653506,0.0004490536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002653808,"about_ca_system_score_gemma":0.0003749546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001532065,"about_ca_topic_score_gemma":0.001858376,"domain_scores_codex":[0.9998036,0.00004425124,0.00002740927,0.00003051014,0.00005374593,0.00004053811],"domain_scores_gemma":[0.9999107,0.00002439506,0.00001382096,0.00001117945,0.00001345437,0.00002644937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002151334,0.0008215451,0.0005353771,0.0002151552,0.0000485169,0.0001471121,0.00004153564,0.0004890698,0.978773,0.0001671714,0.00183924,0.0147709],"study_design_scores_gemma":[0.0003751453,0.005708524,0.005173575,0.0000215447,0.00007543025,0.00034529,0.00003243596,0.001863234,0.9799308,0.00003174598,0.006430401,0.00001196105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780985,0.01011027,0.001348333,0.0003959338,0.0003212972,0.0001404059,0.002032675,0.0002369251,0.007315614],"genre_scores_gemma":[0.9872735,0.002921329,0.002254848,0.0001984309,0.00004807742,0.00009489898,0.002995919,0.00001687145,0.004196173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002520606,"threshold_uncertainty_score":0.008432329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04771243732982426,"score_gpt":0.3602519306785044,"score_spread":0.3125394933486801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}