{"id":"W4282972367","doi":"10.1158/1538-7445.am2022-ct022","title":"Abstract CT022: CheckMate 848: A randomized, open-label, phase 2 study of nivolumab in combination with ipilimumab or nivolumab monotherapy in patients with advanced or metastatic solid tumors of high tumor mutational burden","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; Nivolumab; Ipilimumab; Internal medicine; Oncology; Cohort; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001546705,0.001881615,0.001809103,0.0004969853,0.0004608367,0.001197456,0.001103504,0.001918123,0.01416776],"category_scores_gemma":[0.001469758,0.000675182,0.001448164,0.000464215,0.001008633,0.0009542569,0.0004026042,0.003048349,0.001907854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001088896,"about_ca_system_score_gemma":0.001393904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001340825,"about_ca_topic_score_gemma":0.003727634,"domain_scores_codex":[0.9995124,0.0002595387,0.00002379744,0.00008730897,0.00004514845,0.00007168332],"domain_scores_gemma":[0.9990472,0.0001955028,0.0002116205,0.00006135815,0.00006749725,0.0004167963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9652676,0.009798558,0.001201626,0.0005187491,0.0007590831,0.00005587578,0.00004117712,0.0004129774,0.005478175,0.0001576259,0.003462196,0.01284622],"study_design_scores_gemma":[0.9422287,0.05306535,0.002322045,0.00002319602,0.0002637055,0.00003473349,0.00001090209,0.0003758765,0.000515343,0.00007637679,0.001071096,0.00001269639],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661009,0.003669697,0.0009449662,0.001108732,0.0005767588,0.01264903,0.009132306,0.0003361065,0.005481503],"genre_scores_gemma":[0.9642228,0.00166001,0.002026614,0.002284057,0.0006237253,0.009965267,0.008694563,0.00007402454,0.010449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01416776,"threshold_uncertainty_score":0.04739588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0582001136249899,"score_gpt":0.4146993516726031,"score_spread":0.3564992380476132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}