{"id":"W4282973468","doi":"10.1016/j.kint.2022.05.021","title":"Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies","year":2022,"lang":"en","type":"review","venue":"Kidney International","topic":"Birth, Development, and Health","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medpharmgene (Canada)","funders":"H2020 European Research Council; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Institute of Mental Health; National Institute on Aging; Münchner Zentrum für Gesundheitswissenschaften, Ludwig-Maximilians-Universität München; Biomedical Research Council; National Medical Research Council; Medical Research Council; National Institutes of Health; Sirtex Medical; National Heart, Lung, and Blood Institute; Ministerium für Soziales, Gesundheit, Frauen und Familie, Saarland; National Human Genome Research Institute; Skånes universitetssjukhus; Innovative Medicines Initiative; Region Skåne; Novo Nordisk Fonden; Svenska Diabetesstiftelsen; American Regent; KfH-Stiftung Präventivmedizin; Universitätsklinikum Regensburg; Sigrid Juséliuksen Säätiö; Eunice Kennedy Shriver National Institute of Child Health and Human Development; GlaxoSmithKline; Signe ja Ane Gyllenbergin Säätiö; Paavo Nurmen Säätiö; Sanofi Genzyme; Novo Nordisk; Helse Midt-Norge; Oesterreichische Nationalbank; HORIZON EUROPE Framework Programme; Juho Vainion Säätiö; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Else Kröner-Fresenius-Stiftung; Direktör Albert Påhlssons Stiftelse; Academy of Finland; Erasmus Universiteit Rotterdam; Erasmus Medisch Centrum; Bundesministerium für Forschung und Technologie; Stiftelsen för Strategisk Forskning; Tampereen Tuberkuloosisäätiö; Rijksuniversiteit Groningen; Vetenskapsrådet; Eisai; Fresenius Medical Care North America; U.S. National Library of Medicine; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; Japan Agency for Medical Research and Development; Ministerie van Economische Zaken en Klimaat; Sanofi; Norges Teknisk-Naturvitenskapelige Universitet; Eli Lilly and Company; Emil Aaltosen Säätiö; AstraZeneca; CSL Behring; Yrjö Jahnssonin Säätiö; Juvenile Diabetes Research Foundation United States of America; National Institute of Diabetes and Digestive and Kidney Diseases; Gilead Sciences; Knut och Alice Wallenbergs Stiftelse; Japan Society for the Promotion of Science; Bayer; Yale University; Universitair Medisch Centrum Groningen; Kowa Company; CERN; Suomen Kulttuurirahasto; ZonMw; Pfizer; Bill and Melinda Gates Foundation; Amgen; Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg","keywords":"Genome-wide association study; Prioritization; Genetic association; Meta-analysis; Biology; Gene; Computational biology; Genome; Genetics; Function (biology); Evolutionary biology; Bioinformatics; Medicine; Single-nucleotide polymorphism; Internal medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006948023,0.0003223259,0.002910014,0.000782771,0.00009812383,0.00001813322,0.0001632,0.0002057902,0.001200189],"category_scores_gemma":[0.003244476,0.0002773531,0.001195514,0.0005042428,0.00004945201,0.00006620061,0.0001411339,0.0001887242,0.000002117271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006394508,"about_ca_system_score_gemma":0.001145567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009988566,"about_ca_topic_score_gemma":0.0000651748,"domain_scores_codex":[0.9969583,0.0001543545,0.001407638,0.0005166454,0.0007766212,0.0001864897],"domain_scores_gemma":[0.9959735,0.0009460306,0.001827829,0.0002274541,0.0008136815,0.0002114891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002414842,0.000435896,0.06180665,0.01634437,0.8662496,0.000006585983,0.0006600891,0.00001887796,0.00004255871,0.0009545795,0.01139122,0.0418481],"study_design_scores_gemma":[0.000848241,0.000146938,0.02157119,0.0002900562,0.3382893,0.000003091689,0.00005155741,0.0001170478,0.000007859952,0.0008183441,0.6376318,0.0002245859],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003480865,0.9882864,0.004030498,0.001726503,0.0005687121,0.001123747,0.003787831,0.0000233509,0.0001048932],"genre_scores_gemma":[0.0002984917,0.979858,0.005622597,0.0015162,0.0002556295,0.0003370622,0.01189685,0.00003679826,0.000178334],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6262406,"threshold_uncertainty_score":0.9999679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1526559108588688,"score_gpt":0.3866782311301524,"score_spread":0.2340223202712836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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