{"id":"W4282973468","doi":"10.1016/j.kint.2022.05.021","title":"Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies","year":2022,"lang":"en","type":"review","venue":"Kidney International","topic":"Birth, Development, and Health","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medpharmgene (Canada)","funders":"H2020 European Research Council; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Institute of Mental Health; National Institute on Aging; Münchner Zentrum für Gesundheitswissenschaften, Ludwig-Maximilians-Universität München; Biomedical Research Council; National Medical Research Council; Medical Research Council; National Institutes of Health; Sirtex Medical; National Heart, Lung, and Blood Institute; Ministerium für Soziales, Gesundheit, Frauen und Familie, Saarland; National Human Genome Research Institute; Skånes universitetssjukhus; Innovative Medicines Initiative; Region Skåne; Novo Nordisk Fonden; Svenska Diabetesstiftelsen; American Regent; KfH-Stiftung Präventivmedizin; Universitätsklinikum Regensburg; Sigrid Juséliuksen Säätiö; Eunice Kennedy Shriver National Institute of Child Health and Human Development; GlaxoSmithKline; Signe ja Ane Gyllenbergin Säätiö; Paavo Nurmen Säätiö; Sanofi Genzyme; Novo Nordisk; Helse Midt-Norge; Oesterreichische Nationalbank; HORIZON EUROPE Framework Programme; Juho Vainion Säätiö; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Else Kröner-Fresenius-Stiftung; Direktör Albert Påhlssons Stiftelse; Academy of Finland; Erasmus Universiteit Rotterdam; Erasmus Medisch Centrum; Bundesministerium für Forschung und Technologie; Stiftelsen för Strategisk Forskning; Tampereen Tuberkuloosisäätiö; Rijksuniversiteit Groningen; Vetenskapsrådet; Eisai; Fresenius Medical Care North America; U.S. National Library of Medicine; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; Japan Agency for Medical Research and Development; Ministerie van Economische Zaken en Klimaat; Sanofi; Norges Teknisk-Naturvitenskapelige Universitet; Eli Lilly and Company; Emil Aaltosen Säätiö; AstraZeneca; CSL Behring; Yrjö Jahnssonin Säätiö; Juvenile Diabetes Research Foundation United States of America; National Institute of Diabetes and Digestive and Kidney Diseases; Gilead Sciences; Knut och Alice Wallenbergs Stiftelse; Japan Society for the Promotion of Science; Bayer; Yale University; Universitair Medisch Centrum Groningen; Kowa Company; CERN; Suomen Kulttuurirahasto; ZonMw; Pfizer; Bill and Melinda Gates Foundation; Amgen; Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg","keywords":"Genome-wide association study; Prioritization; Genetic association; Meta-analysis; Biology; Gene; Computational biology; Genome; Genetics; Function (biology); Evolutionary biology; Bioinformatics; Medicine; Single-nucleotide polymorphism; Internal medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01592973,0.002209416,0.00487775,0.00408873,0.0009131543,0.003653143,0.001431938,0.001651538,0.002624677],"category_scores_gemma":[0.01862359,0.001064638,0.02702468,0.006008198,0.0006093401,0.0009071819,0.001843167,0.002175109,0.0003661226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007610096,"about_ca_system_score_gemma":0.00110392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005782444,"about_ca_topic_score_gemma":0.006374978,"domain_scores_codex":[0.9895551,0.004397447,0.001716451,0.002994609,0.0008489484,0.0004873411],"domain_scores_gemma":[0.9812881,0.0129612,0.001886068,0.002414435,0.001012767,0.0004373679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.007011859,0.00004494493,0.3836994,0.003159783,0.5887187,0.0008580011,0.0001622769,0.002451111,0.003779946,0.0002314972,0.0009209995,0.008961538],"study_design_scores_gemma":[0.0008303116,0.0003714999,0.2217048,0.000466235,0.7684085,0.0006499104,0.000157174,0.004209236,0.0009523538,0.0008996434,0.001298723,0.00005152929],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7682434,0.2067172,0.01513096,0.001621764,0.0004936846,0.0002081938,0.005691513,0.0005311703,0.001362057],"genre_scores_gemma":[0.9897843,0.005855782,0.001882684,0.0003009365,0.0001051927,0.00007511827,0.001689143,0.0000847478,0.0002220715],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01592973,"threshold_uncertainty_score":0.08424544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1526559108588688,"score_gpt":0.3866782311301524,"score_spread":0.2340223202712836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}