{"id":"W4282974114","doi":"10.1158/1538-7445.am2022-ct023","title":"Abstract CT023: Nivolumab (NIVO) plus chemotherapy (chemo) vs chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): CheckMate 649 biomarker analyses","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Internal medicine; Nivolumab; Oncology; Cancer; Population; Biomarker; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009446634,0.00088634,0.001474497,0.001273408,0.001599855,0.0001668965,0.0007677941,0.0002039796,0.008287257],"category_scores_gemma":[0.00009668381,0.000829044,0.0007263904,0.002828242,0.0003658909,0.0003510009,0.000381959,0.0009867506,0.00004555098],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0118187,"about_ca_system_score_gemma":0.002289594,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02101723,"about_ca_topic_score_gemma":0.002067302,"domain_scores_codex":[0.9926347,0.0001609685,0.001016029,0.001773788,0.002205839,0.002208691],"domain_scores_gemma":[0.9967684,0.0002802164,0.0004705873,0.001134408,0.000678917,0.0006674457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.06578021,0.002763321,0.127343,0.00297767,0.006363336,0.001271582,0.002240979,0.01953842,0.05689401,0.00009618263,0.08833942,0.6263919],"study_design_scores_gemma":[0.1076712,0.01250004,0.633971,0.0008702662,0.002645132,0.0002213345,0.003688758,0.01117754,0.09052913,0.0002948969,0.133924,0.002506634],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9587504,0.02206836,0.000246009,0.01026014,0.001700753,0.005237998,0.0006417147,0.0003183782,0.0007762194],"genre_scores_gemma":[0.9515656,0.009660996,0.0003310475,0.0008352849,0.001582041,0.01058319,0.0004700011,0.0002534931,0.0247183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6238853,"threshold_uncertainty_score":0.9997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1315698116237094,"score_gpt":0.4390292633664952,"score_spread":0.3074594517427859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}