{"id":"W4282974114","doi":"10.1158/1538-7445.am2022-ct023","title":"Abstract CT023: Nivolumab (NIVO) plus chemotherapy (chemo) vs chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): CheckMate 649 biomarker analyses","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Internal medicine; Nivolumab; Oncology; Cancer; Population; Biomarker; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001035734,0.0005078168,0.0009595088,0.0003262566,0.0002052289,0.0006787963,0.0004364927,0.0005929216,0.006135024],"category_scores_gemma":[0.0009954456,0.0001882553,0.001498722,0.0003533894,0.0003628152,0.0004380905,0.000239474,0.001116267,0.0005120817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001173861,"about_ca_system_score_gemma":0.0008643167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001055761,"about_ca_topic_score_gemma":0.003400072,"domain_scores_codex":[0.9995927,0.0002038535,0.00002688902,0.00008322989,0.00004546461,0.00004771207],"domain_scores_gemma":[0.9994023,0.0001550425,0.0001595003,0.00004338351,0.00004559958,0.000194085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8676028,0.005215201,0.01958847,0.0008381052,0.003431324,0.00008060504,0.00007563353,0.00272184,0.02635684,0.0002880929,0.003448779,0.07035236],"study_design_scores_gemma":[0.3350636,0.4800805,0.1293988,0.0002501401,0.0103304,0.0005119285,0.0001666528,0.00911795,0.02300745,0.0009054107,0.01106239,0.0001048157],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938188,0.001682174,0.0002225151,0.0002750912,0.0000848359,0.0004534056,0.001899906,0.00004035968,0.001522818],"genre_scores_gemma":[0.9942847,0.0003949199,0.0005663115,0.0003630389,0.00005282705,0.0004625513,0.002123617,0.0000122787,0.001739707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006135024,"threshold_uncertainty_score":0.02052367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1315698116237094,"score_gpt":0.4390292633664952,"score_spread":0.3074594517427859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}