{"id":"W4282974171","doi":"10.1158/1538-7445.am2022-1076","title":"Abstract 1076: The peptide-drug conjugate TH1902 inhibits growth of subcutaneous melanoma xenografts and formation of lung metastases in a syngeneic mouse model","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Theratechnologies (Canada)","funders":"","keywords":"Docetaxel; Melanoma; Medicine; Lung; Cancer research; Subcutaneous injection; Cancer; Lung cancer; Pharmacology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211818,0.0004745488,0.0002732372,0.0002286708,0.00008269572,0.0002032521,0.0001783272,0.0003901763,0.002008473],"category_scores_gemma":[0.00006359704,0.0001307831,0.0002003515,0.0001193395,0.0001384351,0.0001466423,0.00007087611,0.0007897877,0.0005988197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002596749,"about_ca_system_score_gemma":0.0002189198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008848563,"about_ca_topic_score_gemma":0.001159527,"domain_scores_codex":[0.9998864,0.00002172779,0.000008525781,0.00002025262,0.00003613189,0.0000269166],"domain_scores_gemma":[0.9999321,0.000010512,0.00001779109,0.000008078407,0.000007123176,0.00002442704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002821311,0.0001540491,0.00008446122,0.00002087991,0.000004285434,0.00002809801,0.00000474115,0.000083469,0.9982534,0.00003746582,0.0001037546,0.0009433131],"study_design_scores_gemma":[0.00008394889,0.002539897,0.001133708,0.000002989069,0.000009321891,0.0001430473,0.000007105937,0.0008377634,0.9941712,0.00001018178,0.00105852,0.00000221202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929796,0.0009481077,0.001936993,0.0001474094,0.00007517658,0.00008068739,0.0007656188,0.0001430638,0.002923476],"genre_scores_gemma":[0.9908301,0.000671865,0.001952981,0.0000616977,0.00001860035,0.00006053362,0.0009477847,0.0000285843,0.005427915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002008473,"threshold_uncertainty_score":0.006718993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02976119661809746,"score_gpt":0.3164540540785309,"score_spread":0.2866928574604334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}