{"id":"W4282974204","doi":"10.1158/1538-7445.am2022-1508","title":"Abstract 1508: Chromatin accessibility of primary human cancers ties regional mutational processes with tissues of origin","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Biology; Chromatin; Genetics; Epigenetics; Mutagenesis; Computational biology; Insertional mutagenesis; Genome; Mutation; Context (archaeology); Point mutation; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002179609,0.0002096131,0.0003588362,0.0002122238,0.0001346193,0.0004146702,0.0004449685,0.000324412,0.00320614],"category_scores_gemma":[0.0008552037,0.0001535491,0.0005564221,0.0003183672,0.0003208815,0.0002146042,0.0002378509,0.0002796516,0.0002838563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004823996,"about_ca_system_score_gemma":0.0004383601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009411891,"about_ca_topic_score_gemma":0.006465187,"domain_scores_codex":[0.9999025,0.0000235055,0.000003757091,0.00004480856,0.00001122568,0.0000141308],"domain_scores_gemma":[0.9997612,0.0001335114,0.00003587532,0.00002759043,0.00002066853,0.00002129312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.00009311845,0.00003238018,0.03468974,0.00004022786,0.00006910894,0.00008084533,0.00001751521,0.9560294,0.00384885,0.001351956,0.0003654484,0.003381404],"study_design_scores_gemma":[0.00001018615,0.00003909866,0.01671418,0.000003708722,0.00002310035,0.00006004172,0.00001283569,0.9788349,0.0009895897,0.003012754,0.0002938909,0.000005686693],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647996,0.0001728544,0.03082082,0.0001304375,0.00001286852,0.00001967929,0.002240574,0.0001965568,0.001606589],"genre_scores_gemma":[0.9965895,0.00006720207,0.002002855,0.00001675952,0.000003793028,0.00001531634,0.0007966535,0.00001640648,0.0004915191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009411891,"threshold_uncertainty_score":0.01871425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0750129453810466,"score_gpt":0.4012203816539157,"score_spread":0.3262074362728691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}