{"id":"W4282975154","doi":"10.1016/j.it.2022.05.004","title":"Mutagenic repair during antibody diversification: emerging insights","year":2022,"lang":"en","type":"article","venue":"Trends in Immunology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cytidine deaminase; Antibody; Activation-induced (cytidine) deaminase; Biology; DNA repair; Base excision repair; Pathogenesis; Immunology; DNA mismatch repair; Cytidine; Somatic hypermutation; Immunoglobulin class switching; Diversification (marketing strategy); Gene; Genetics; B cell; Enzyme; Biochemistry; Business","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195727,0.0001285571,0.000137935,0.000276942,0.0002225982,0.000004959758,0.000307588,0.00008805825,0.0004983564],"category_scores_gemma":[0.0000174384,0.0001524387,0.000113026,0.0003395249,0.00005695192,0.000004449635,0.0005963754,0.0001925521,0.00001427923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006635353,"about_ca_system_score_gemma":0.00002600277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002770437,"about_ca_topic_score_gemma":0.00002216588,"domain_scores_codex":[0.9988258,0.0001650946,0.0002152097,0.0004235487,0.0001021631,0.0002681621],"domain_scores_gemma":[0.9993398,0.000005928559,0.00008011753,0.0005338044,0.00001773643,0.0000226298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000119546,0.00009359732,0.002277813,0.000003933864,0.00008370808,0.00005069414,0.0003121347,0.0001713676,0.9942992,0.0005990053,0.00016428,0.00182472],"study_design_scores_gemma":[0.00404997,0.001249628,0.1587448,0.00001107096,0.00005367812,0.0004242691,0.00280726,0.0004086232,0.6735046,0.0004132051,0.1573835,0.0009494153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951413,0.001805897,0.00003669741,0.0001024446,0.000468161,0.00006033167,0.000007001856,0.00007382702,0.002304345],"genre_scores_gemma":[0.9959336,0.0001076352,0.0002715294,0.00005409015,0.0000511751,0.00005444246,0.0002728138,0.00002103219,0.003233698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3207946,"threshold_uncertainty_score":0.6216269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046523756314956,"score_gpt":0.2622452476925692,"score_spread":0.2517800101294197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}