{"id":"W4282975806","doi":"10.1158/1538-7445.am2022-2625","title":"Abstract 2625: Personalized chemotherapy treatments for microsatellite instable tumors","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal General Hospital","funders":"","keywords":"Microsatellite instability; Organoid; Cancer; Chemotherapy; Medicine; Cancer research; Biology; Mutation; Oncology; Bioinformatics; Internal medicine; Microsatellite; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002537615,0.0003456004,0.0003652634,0.0004441811,0.0001982662,0.0005961432,0.0002829835,0.0003673601,0.006344995],"category_scores_gemma":[0.0001584799,0.00009930157,0.0002366048,0.0004169382,0.0001819787,0.000234538,0.0002921991,0.000588284,0.001708695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000500364,"about_ca_system_score_gemma":0.0003630416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004076409,"about_ca_topic_score_gemma":0.001554024,"domain_scores_codex":[0.9998813,0.00001875577,0.00000842297,0.00002633671,0.00004833578,0.00001672043],"domain_scores_gemma":[0.9999275,0.00001118364,0.00001968215,0.000007786241,0.00001472398,0.00001911178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001255134,0.0005181259,0.009122195,0.00148825,0.0001437862,0.001140755,0.0001321801,0.002593142,0.6378357,0.002310383,0.01936597,0.3240943],"study_design_scores_gemma":[0.0005478047,0.005917208,0.05703875,0.0004133337,0.0004400456,0.006901298,0.0001625883,0.004895373,0.5571993,0.001905763,0.3645025,0.00007602287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7580529,0.1251974,0.0401921,0.006787645,0.001221896,0.00100196,0.01071334,0.002114133,0.05471859],"genre_scores_gemma":[0.8750383,0.04968202,0.02685222,0.001688926,0.0003812911,0.0004566945,0.00874978,0.0001561481,0.03699458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006344995,"threshold_uncertainty_score":0.02122617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1147024497603898,"score_gpt":0.4334959040853583,"score_spread":0.3187934543249684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}