{"id":"W4282976130","doi":"10.1158/1538-7445.am2022-1844","title":"Abstract 1844: Anti-tumor activity of a dual BET/CBP/EP300 inhibitor, NEO2734, in undifferentiated pleomorphic sarcomas and identification of genes involved in resistance","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Society for Arts and Technology","funders":"","keywords":"Bromodomain; Cancer research; Sarcoma; Biology; BET inhibitor; Rhabdomyosarcoma; Gene; Epigenetics; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002053234,0.0003076618,0.0004001765,0.0003958895,0.0001456669,0.0001810255,0.0002567524,0.0002730791,0.002565633],"category_scores_gemma":[0.0001723839,0.0001388167,0.000346907,0.0002492137,0.0002343449,0.000146977,0.0001552086,0.0006572292,0.0004583603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002243411,"about_ca_system_score_gemma":0.0002073599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008368671,"about_ca_topic_score_gemma":0.001046369,"domain_scores_codex":[0.9998959,0.00002684744,0.000009600568,0.00001361077,0.00002605358,0.00002788211],"domain_scores_gemma":[0.9998952,0.00003591786,0.00001240764,0.00001328933,0.00001530849,0.00002792174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00242033,0.001039637,0.001316485,0.0001794208,0.00003360633,0.0002534479,0.00004438956,0.0003523874,0.981061,0.00007542864,0.0003550717,0.01286888],"study_design_scores_gemma":[0.0006014631,0.02079941,0.02589388,0.00001443062,0.0001357486,0.001177388,0.00007105927,0.001638809,0.9456495,0.00006238896,0.003944983,0.00001100764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995223,0.00183562,0.000543952,0.00008391733,0.00002801154,0.00007299567,0.0004833781,0.00003596317,0.001693189],"genre_scores_gemma":[0.9917019,0.001436468,0.0009134599,0.00006653457,0.00002159485,0.00007006887,0.00176354,0.00001112334,0.004015377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002565633,"threshold_uncertainty_score":0.00858289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04516344419988888,"score_gpt":0.3372830173146622,"score_spread":0.2921195731147733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}