{"id":"W4282977144","doi":"10.1007/s00262-022-03228-y","title":"Acidosis significantly alters immune checkpoint expression profiles of T cells from oesophageal adenocarcinoma patients","year":2022,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Irish Research Council; Irish Research Council for Science, Engineering and Technology; Irish Research eLibrary","keywords":"Immune checkpoint; Immune system; Cancer research; Acidosis; Adenocarcinoma; Medicine; Internal medicine; Immunology; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001333253,0.0002118187,0.0002917381,0.0003021991,0.0002004163,0.000380789,0.0001273119,0.0002569249,0.005804931],"category_scores_gemma":[0.0002467986,0.0001065178,0.0003149792,0.0002714751,0.000113576,0.000132313,0.0002363764,0.0005014292,0.0006127082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001675522,"about_ca_system_score_gemma":0.0001476436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007161706,"about_ca_topic_score_gemma":0.0007825322,"domain_scores_codex":[0.9998695,0.0000242072,0.00001195959,0.00003637676,0.00002630327,0.00003166837],"domain_scores_gemma":[0.9999231,0.00001352224,0.00001963475,0.000005187984,0.00001625117,0.00002233169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02147159,0.0004904893,0.1554882,0.001584911,0.0003277824,0.001895332,0.0007373421,0.0009218329,0.7457514,0.0003146955,0.005526094,0.06549032],"study_design_scores_gemma":[0.0007720065,0.008239162,0.7548152,0.0002420627,0.0006584367,0.004759397,0.002205866,0.002529704,0.1977385,0.0007562835,0.02719896,0.00008429947],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889719,0.003953364,0.0009212082,0.000273724,0.0001268007,0.00007454173,0.003964464,0.00003810721,0.001675846],"genre_scores_gemma":[0.9931611,0.001329466,0.0004920455,0.0002043842,0.00004353496,0.00008300164,0.003036884,0.000008927713,0.001640558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005804931,"threshold_uncertainty_score":0.01941943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401618461131364,"score_gpt":0.2539326952524399,"score_spread":0.2399165106411262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}