{"id":"W4282978282","doi":"10.1158/1538-7445.am2022-538","title":"Abstract 538: Cell-free whole genome sequencing for the detection of cancer in patients with germline <i>BRCA1/2</i> mutations","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Germline; Ovarian cancer; Breast cancer; Cancer; Germline mutation; Digital polymerase chain reaction; Biology; Cancer research; Internal medicine; Medicine; Oncology; Mutation; Genetics; Gene; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006829177,0.0004287112,0.0003585124,0.0009178997,0.0004179117,0.0006958502,0.0004738299,0.0005761978,0.004275473],"category_scores_gemma":[0.001655954,0.0002140073,0.0002992871,0.0006473032,0.0002227222,0.0001553192,0.0003740939,0.0004204391,0.001532858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006021042,"about_ca_system_score_gemma":0.0008238931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01449779,"about_ca_topic_score_gemma":0.03032924,"domain_scores_codex":[0.9994326,0.00006227137,0.00003135659,0.0002170624,0.0002000725,0.00005666148],"domain_scores_gemma":[0.9994703,0.0001322465,0.00006045857,0.0000641091,0.0001970384,0.00007583638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003183163,0.0002304728,0.513275,0.0006739232,0.0004044492,0.00151737,0.000811837,0.003155116,0.269816,0.0006896092,0.0368083,0.1694348],"study_design_scores_gemma":[0.0002498668,0.0007857704,0.7828255,0.0001978859,0.0003998788,0.00570815,0.000351766,0.02140547,0.14437,0.0008018062,0.04281633,0.00008769829],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.930079,0.002654912,0.01777187,0.0006912244,0.000125525,0.0003338435,0.03944354,0.002658456,0.006241513],"genre_scores_gemma":[0.9230959,0.000669979,0.03547831,0.0007546172,0.00006697673,0.0002357059,0.03449922,0.0006296433,0.004569551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01449779,"threshold_uncertainty_score":0.02882677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02517415277626236,"score_gpt":0.3193909574214359,"score_spread":0.2942168046451736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}