{"id":"W4282978307","doi":"10.1371/journal.pgen.1009840","title":"The distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii inferred using frequency changes under experimental evolution","year":2022,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"H2020 European Research Council; European Commission","keywords":"Biology; Chlamydomonas reinhardtii; Genetics; Mutation; Mutation rate; Allele frequency; Population; Mutation Accumulation; Selection (genetic algorithm); Natural selection; Population genetics; Chlamydomonas; Evolutionary biology; Genotype; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000111311,0.0001118434,0.0001279279,0.00004345567,0.0001600814,0.000005754998,0.0001721022,0.00006886107,0.000007351669],"category_scores_gemma":[0.00005990175,0.000111532,0.00005385264,0.0001843439,0.0001383618,0.000001784405,0.0001561432,0.00008227042,3.312232e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001236611,"about_ca_system_score_gemma":0.0001188444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003280841,"about_ca_topic_score_gemma":0.0001911778,"domain_scores_codex":[0.998997,0.0001498988,0.0002581873,0.0001871885,0.0002259227,0.0001818133],"domain_scores_gemma":[0.9994284,0.00003557254,0.0001538811,0.0002640777,0.00008528677,0.00003278868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004895819,0.0002178609,0.002090234,0.00003148551,0.00003609892,0.000005060113,0.0001166076,0.03916305,0.9576788,0.0005148915,0.00001338927,0.00008356856],"study_design_scores_gemma":[0.001183866,0.0009766875,0.01699572,0.00003315953,0.00007446814,0.00009728233,0.00111613,0.06718725,0.9109503,0.0009064609,0.0001818156,0.0002968381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933664,0.003833776,0.002140835,0.00004392608,0.0001682691,0.00031945,0.00008626818,0.000005263948,0.00003582983],"genre_scores_gemma":[0.999213,0.00009549673,0.0002181489,0.00001623764,0.0000352569,0.00005356682,0.0003079413,0.00001565402,0.00004469602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04672847,"threshold_uncertainty_score":0.4548141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129531291997859,"score_gpt":0.2531152570991022,"score_spread":0.2418199441791236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}