{"id":"W4282979207","doi":"10.1158/1538-7445.am2022-346","title":"Abstract 346: Synergistic antiproliferative activity of novel RAD51 inhibitor JKYN-1 and its mesylate salt with standard-of-care cancer drugs","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Ontario Institute for Cancer Research; London Health Sciences Centre","funders":"","keywords":"Cancer cell; Cancer; Cytotoxicity; Cancer research; Chemistry; Pharmacology; RAD51; Cell growth; Biology; In vitro; DNA repair; DNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059257,0.0004535453,0.0005592051,0.0003645054,0.0001409235,0.0001712721,0.0003757705,0.0002356078,0.003498551],"category_scores_gemma":[0.00008447559,0.0001485216,0.000270063,0.000240592,0.0001147161,0.0002246878,0.000267907,0.0004560437,0.0006255187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001964722,"about_ca_system_score_gemma":0.0003205393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006425909,"about_ca_topic_score_gemma":0.001160123,"domain_scores_codex":[0.9999195,0.00001375712,0.000009239046,0.00001657928,0.00002201367,0.00001877653],"domain_scores_gemma":[0.9999727,0.000003166093,0.000005457918,0.000002556102,0.000003664895,0.00001241898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002025628,0.0005818983,0.0002806762,0.0004677086,0.00005688193,0.0002143145,0.00003353414,0.0009598625,0.9736426,0.0003264606,0.001142506,0.02026785],"study_design_scores_gemma":[0.0005902945,0.005066143,0.002796421,0.00003288311,0.0001184768,0.0004982997,0.00002764642,0.00274321,0.9773563,0.00007854101,0.0106627,0.00002917714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789528,0.01029251,0.001794598,0.0002503875,0.0002377765,0.0001636425,0.0007500369,0.0002278292,0.00733058],"genre_scores_gemma":[0.9923103,0.002711657,0.00128261,0.00007483117,0.00002250262,0.00005293557,0.0006920359,0.00001796361,0.00283526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003498551,"threshold_uncertainty_score":0.01170385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04368471514293023,"score_gpt":0.3729548311705984,"score_spread":0.3292701160276681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}