{"id":"W4282979246","doi":"10.1158/1538-7445.am2022-5135","title":"Abstract 5135: Antitumor activity of dostarlimab by PD-L1 and tumor mutation burden (TMB) in patients (pts) with mismatch repair deficient and proficient (dMMR and MMRp) tumors in the GARNET trial","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre Hospitalier de l’Université de Montréal; Kelowna General Hospital","funders":"","keywords":"Medicine; Internal medicine; Oncology; Discontinuation; Cancer; Regimen; Cohort; DNA mismatch repair; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001445347,0.0008571824,0.00129008,0.0002529474,0.0001918816,0.0007522195,0.0004326605,0.000629899,0.003328048],"category_scores_gemma":[0.0005674587,0.0002760573,0.0009579106,0.0003056064,0.0006345215,0.0007534401,0.0004311931,0.001765711,0.0004966335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008162833,"about_ca_system_score_gemma":0.0008806452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003431407,"about_ca_topic_score_gemma":0.001367524,"domain_scores_codex":[0.9995537,0.0002529033,0.00002462297,0.00007298217,0.00003817876,0.00005755322],"domain_scores_gemma":[0.9996303,0.00007134366,0.00009269778,0.00003796807,0.00001691673,0.0001507562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8306813,0.01059955,0.01993667,0.0008107658,0.001534416,0.0001592276,0.0002285313,0.003399096,0.04221795,0.0003474153,0.003503982,0.08658116],"study_design_scores_gemma":[0.4242609,0.4900225,0.05860565,0.0001043222,0.002243392,0.0006174404,0.0001347764,0.003738475,0.01192877,0.0006641976,0.007619981,0.00005974179],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996756,0.001118386,0.0001240044,0.0002269717,0.00002598101,0.0002869549,0.0004348484,0.00004726508,0.0009795966],"genre_scores_gemma":[0.9962347,0.0004470834,0.000429363,0.0002582036,0.00004039325,0.0003463441,0.00114923,0.00001360667,0.001081101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003328048,"threshold_uncertainty_score":0.01113343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04054549974714571,"score_gpt":0.3534296910819437,"score_spread":0.3128841913347979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}