{"id":"W4282980664","doi":"10.1158/1538-7445.am2022-670","title":"Abstract 670: Distinct biochemical properties of KRAS Q61H mutant render cancer cells resistant to SHP2 inhibitors","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"KRAS; Phosphorylation; Cancer research; GTPase; Biology; Mutant; Kinase; MAPK/ERK pathway; Signal transduction; HEK 293 cells; Mutation; Cell biology; Chemistry; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003941976,0.0001976168,0.0001899696,0.000087858,0.0001164145,0.0001988272,0.0001303374,0.0001814913,0.001870454],"category_scores_gemma":[0.0000482856,0.0001052857,0.0001777928,0.0001084126,0.0001083407,0.0001050017,0.0001132125,0.0002544806,0.0004391443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001600978,"about_ca_system_score_gemma":0.0001180013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077601,"about_ca_topic_score_gemma":0.0006592385,"domain_scores_codex":[0.9999532,0.000003730105,0.000003411296,0.000007478549,0.00002139505,0.00001082912],"domain_scores_gemma":[0.9999727,0.000004079317,0.000008373857,0.000002850768,0.000004289544,0.000007728231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008223434,0.00002010358,0.0002672475,0.00002176854,0.000006256199,0.00005891378,0.00001018667,0.0003404849,0.9979057,0.0001641323,0.00007661839,0.001046357],"study_design_scores_gemma":[0.0000209018,0.0002240481,0.004951081,0.000004966255,0.00001193411,0.0002519828,0.00003744726,0.005768855,0.9863765,0.0001378799,0.002205367,0.000009138646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962525,0.0003264284,0.00136025,0.00007002494,0.00001788203,0.00001389717,0.0004076096,0.00006335246,0.001488012],"genre_scores_gemma":[0.9965417,0.0002228641,0.0007337899,0.00003271015,0.000002505412,0.00001427188,0.0006132206,0.00002219208,0.001816781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001870454,"threshold_uncertainty_score":0.006257296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05409330705535739,"score_gpt":0.3475781959780369,"score_spread":0.2934848889226795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}