{"id":"W4282980863","doi":"10.1002/rth2.12737","title":"Identification of von Willebrand factor D4 domain mutations in patients of Afro‐Caribbean descent: In vitro characterization","year":2022,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Von Willebrand factor; Von Willebrand disease; Mutant; Wild type; Recombinant DNA; Mutation; Allele; HEK 293 cells; In vitro; Gene; Molecular biology; Genetics; Biology; Platelet; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052193,0.0003386822,0.0001954023,0.0004514868,0.0002975863,0.0002735735,0.0001579933,0.0004783741,0.001359269],"category_scores_gemma":[0.0004235281,0.0001266949,0.0002212969,0.0002863322,0.0001354174,0.00006555022,0.0001835739,0.0002374358,0.0002861526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002456091,"about_ca_system_score_gemma":0.0001603219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003052447,"about_ca_topic_score_gemma":0.001959254,"domain_scores_codex":[0.9998884,0.00001745163,0.000014096,0.00002945716,0.00002082733,0.00002974803],"domain_scores_gemma":[0.9999063,0.00003396446,0.0000211238,0.000007928536,0.000009887786,0.00002081107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001400199,0.0002518478,0.326242,0.0001503935,0.0001211876,0.02905305,0.0009921866,0.0003512878,0.6234326,0.0002703982,0.0004827602,0.01725201],"study_design_scores_gemma":[0.000154875,0.001258295,0.7356693,0.00004470023,0.0002293014,0.1108329,0.000713087,0.002329956,0.1405802,0.0001756752,0.00797634,0.00003531153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991968,0.0001756515,0.0001904119,0.00002993436,0.000004056015,0.000009296566,0.0001026063,0.000003599374,0.0002876184],"genre_scores_gemma":[0.9991848,0.0001122481,0.0002467121,0.0000241562,0.000005101367,0.00000721898,0.0002360735,0.00000281743,0.0001809811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003052447,"threshold_uncertainty_score":0.006069362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07238378692664654,"score_gpt":0.3822112693295903,"score_spread":0.3098274824029438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}