{"id":"W4282981378","doi":"10.2144/btn-2022-0062","title":"Building a baby: Are Stem Cell-Based, Embryo-Like Models the Key to Unlocking the Secrets of Human Development?","year":2022,"lang":"en","type":"article","venue":"BioTechniques","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Dilemma; Stem cell; Embryonic stem cell; Key (lock); Biology; Engineering ethics; Ethical dilemma; Environmental ethics; Cell biology; Genetics; Epistemology; Engineering; Philosophy; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008541599,0.0001711241,0.0001491268,0.00009176505,0.0005989277,0.00003699086,0.0009202618,0.0001052615,0.00001693866],"category_scores_gemma":[0.000008009329,0.0001200106,0.00009465805,0.0002364957,0.00007518012,0.000003745099,0.0009832184,0.0002625646,0.00000148827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007045107,"about_ca_system_score_gemma":0.000156243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000553262,"about_ca_topic_score_gemma":0.00002063378,"domain_scores_codex":[0.998351,0.0002480901,0.0002681192,0.0003682113,0.0004372128,0.0003273667],"domain_scores_gemma":[0.9990544,0.00002703537,0.0001444931,0.0006250068,0.00008696362,0.00006207611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004571067,0.00005013506,0.0001062625,0.00004212615,0.00002415898,0.000004415346,0.0002229524,0.001708558,0.9931647,0.0001271841,0.003263891,0.001239876],"study_design_scores_gemma":[0.0001314602,0.0002121736,0.00009213501,0.00002918737,0.000006797201,0.000004562643,0.0002274315,0.0005139874,0.9467633,0.00007053072,0.05178586,0.0001626279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673064,0.0007082678,0.02928694,0.0006827638,0.00005162834,0.0008911552,0.000029187,0.00006665397,0.0009769979],"genre_scores_gemma":[0.9955415,0.00002287514,0.002871537,0.0005125692,0.0000409322,0.0002493437,0.00002327574,0.00003505213,0.0007029552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04852197,"threshold_uncertainty_score":0.4893889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02916033122282306,"score_gpt":0.2817074900721894,"score_spread":0.2525471588493663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}