{"id":"W4282981378","doi":"10.2144/btn-2022-0062","title":"Building a baby: Are Stem Cell-Based, Embryo-Like Models the Key to Unlocking the Secrets of Human Development?","year":2022,"lang":"en","type":"article","venue":"BioTechniques","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Dilemma; Stem cell; Embryonic stem cell; Key (lock); Biology; Engineering ethics; Ethical dilemma; Environmental ethics; Cell biology; Genetics; Epistemology; Engineering; Philosophy; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006278087,0.0004898686,0.0007024495,0.000372371,0.0009077889,0.002846123,0.00122438,0.002507633,0.005331601],"category_scores_gemma":[0.008947819,0.0003268683,0.0003018144,0.0003172764,0.007367182,0.006737059,0.002027553,0.004430456,0.003051903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007441211,"about_ca_system_score_gemma":0.001332705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004923625,"about_ca_topic_score_gemma":0.0006739101,"domain_scores_codex":[0.9986443,0.0006283119,0.00004933022,0.0001142266,0.0004698433,0.00009406028],"domain_scores_gemma":[0.9967377,0.001654624,0.0002775732,0.0004997175,0.0003891316,0.0004412524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001102476,0.0002635988,0.002770362,0.001841803,0.00005956764,0.001185869,0.003589413,0.0005997102,0.08710377,0.5835983,0.09489095,0.2229941],"study_design_scores_gemma":[0.0000934036,0.000963841,0.001146827,0.001009309,0.00008164487,0.003234655,0.002511596,0.0008008156,0.05878836,0.224204,0.7070663,0.00009926523],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.06445333,0.2745251,0.1513857,0.41097,0.0213319,0.000266704,0.0009478685,0.001058854,0.07506064],"genre_scores_gemma":[0.3895142,0.3627778,0.1072348,0.08767212,0.003707654,0.0005689983,0.00101717,0.001071223,0.0464361],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006278087,"threshold_uncertainty_score":0.03320205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02916033122282306,"score_gpt":0.2817074900721894,"score_spread":0.2525471588493663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}