{"id":"W4282983004","doi":"10.1158/1538-7445.am2022-ct006","title":"Abstract CT006: Phase Ib expansion trial of the safety and efficacy of the oral ataxia telangiectasia and Rad3-related (ATR) inhibitor elimusertib in advanced solid tumors with DNA damage response (DDR) defects","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Medicine; Cancer; Internal medicine; Oncology; Adverse effect; Prostate cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008032056,0.001693674,0.001121136,0.0003743903,0.0004005274,0.0009908085,0.0008398647,0.00102598,0.01122897],"category_scores_gemma":[0.000671762,0.0003483285,0.0008961871,0.0005107214,0.0006813334,0.0006055523,0.00038755,0.003088917,0.002112939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001066975,"about_ca_system_score_gemma":0.001632739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00147782,"about_ca_topic_score_gemma":0.003711336,"domain_scores_codex":[0.9997748,0.00008921909,0.00001284134,0.00003798974,0.0000358327,0.00004929379],"domain_scores_gemma":[0.9996443,0.00003702844,0.00006078287,0.00002423182,0.00002933278,0.0002044023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7928061,0.02936597,0.004957905,0.001046381,0.0007355884,0.0003728559,0.0001743743,0.002997237,0.08280557,0.0005717912,0.01503119,0.06913508],"study_design_scores_gemma":[0.6106642,0.3565395,0.01486953,0.00007254555,0.0005360166,0.0006149966,0.00006261408,0.001614355,0.007479099,0.0003428877,0.007165669,0.00003854916],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726504,0.002163871,0.0009251829,0.0008591352,0.0002073503,0.004522683,0.008521173,0.0003560941,0.009794042],"genre_scores_gemma":[0.961225,0.00203336,0.002242607,0.001290845,0.0002644865,0.003936418,0.018153,0.00007478484,0.01077952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01122897,"threshold_uncertainty_score":0.03756469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901895122858206,"score_gpt":0.3431111227698229,"score_spread":0.3240921715412408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}