{"id":"W4282984166","doi":"10.1158/1538-7445.am2022-5205","title":"Abstract 5205: VG2025: Transcriptional and translational dually regulated (TTDR) oncolytic virus for cancer immunotherapy","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada)","funders":"","keywords":"Oncolytic virus; Virus; Internal ribosome entry site; Biology; Viral replication; Cancer research; microRNA; Cell culture; Virology; Gene; Molecular biology; Messenger RNA; Translation (biology); Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002698203,0.0005183094,0.0002082882,0.0003486677,0.0001414989,0.0004339551,0.0003103752,0.0004975498,0.002808955],"category_scores_gemma":[0.0001215426,0.0001136361,0.0002581088,0.0003531121,0.0002091101,0.000218378,0.0002755869,0.0006005046,0.001800917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006242635,"about_ca_system_score_gemma":0.0002232601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005877995,"about_ca_topic_score_gemma":0.0004560674,"domain_scores_codex":[0.9997942,0.00003294836,0.00001509472,0.00004184377,0.00008007228,0.00003582666],"domain_scores_gemma":[0.9999459,0.000005396121,0.00001686557,0.000007509784,0.00001146373,0.00001292954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000192854,0.0000478148,0.0001617654,0.00008290766,0.000007028485,0.00005244322,0.00001523603,0.0001898885,0.9889297,0.0008023001,0.0009914339,0.008526633],"study_design_scores_gemma":[0.0000480116,0.0005459145,0.00128377,0.0000241761,0.0000255127,0.0007763065,0.00001183006,0.001355507,0.9601474,0.0002088265,0.03556215,0.0000106932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8519556,0.01569073,0.08973181,0.0007661137,0.0007359284,0.0007331261,0.007279569,0.002243879,0.03086326],"genre_scores_gemma":[0.9382499,0.002505044,0.02569636,0.0002706661,0.00007038494,0.0002877233,0.009199864,0.0002200794,0.02349996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002808955,"threshold_uncertainty_score":0.009396911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06407653571937082,"score_gpt":0.4057102329477719,"score_spread":0.3416336972284011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}