{"id":"W4283010046","doi":"10.1101/gad.348982.121","title":"Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci","year":2022,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; University Health Network; University of Toronto; Université de Montréal; Université Laval; Montreal Clinical Research Institute; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Centre hospitalier de l'Université Laval; Princess Margaret Cancer Centre; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; University of Toronto","keywords":"Biology; Chromosomal translocation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003182931,0.0002260008,0.0001972322,0.0001441145,0.000290238,0.00002932632,0.0003006755,0.00006849643,0.00021692],"category_scores_gemma":[0.00002074884,0.0002481452,0.00007447968,0.000269968,0.00002902056,0.000003831075,0.0002501004,0.0001062512,0.00001710461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001195896,"about_ca_system_score_gemma":0.0003663766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000574785,"about_ca_topic_score_gemma":0.0002598823,"domain_scores_codex":[0.9982551,0.0001409181,0.0003727891,0.0005131697,0.000318534,0.0003994979],"domain_scores_gemma":[0.9993711,0.00001186968,0.00007212273,0.0003109969,0.00005310811,0.0001807883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002824204,0.000622445,0.02460234,0.00004915696,0.0001459041,0.00001992509,0.003147327,0.009693101,0.8154989,0.0001878823,0.002073289,0.1436773],"study_design_scores_gemma":[0.0005231671,0.0001982992,0.02277903,0.000008757807,0.000008558904,0.000004210458,0.000260492,0.0001208608,0.420389,0.0001455946,0.5552128,0.0003492315],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790896,0.01010405,0.00826762,0.0009562757,0.0003150164,0.0005586538,0.00005244782,0.00002291,0.0006334788],"genre_scores_gemma":[0.981994,0.0003298839,0.01553802,0.0003736161,0.00008136225,0.0004261092,0.0007877417,0.0000353171,0.0004339605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5531395,"threshold_uncertainty_score":0.9999971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247891315816689,"score_gpt":0.2626690388675071,"score_spread":0.2401901257093403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}