{"id":"W4283010601","doi":"10.1007/s13346-022-01190-x","title":"Rapidly dissolving bilayer microneedles enabling minimally invasive and efficient protein delivery to the posterior segment of the eye","year":2022,"lang":"en","type":"article","venue":"Drug Delivery and Translational Research","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast","keywords":"Bilayer; Posterior segment of eyeball; Biomedical engineering; Computer science; Ophthalmology; Medicine; Chemistry; Membrane","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001621487,0.0001998754,0.0001242196,0.0001660174,0.00008743119,0.0002348282,0.00008421692,0.0003004304,0.0003572459],"category_scores_gemma":[0.0001752163,0.0001334882,0.0001678887,0.00007327098,0.0001332099,0.0002565633,0.00017815,0.0002385629,0.0001672454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002105377,"about_ca_system_score_gemma":0.0001465087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004586724,"about_ca_topic_score_gemma":0.001058666,"domain_scores_codex":[0.9998995,0.00001048959,0.000009273286,0.00002164724,0.00004568748,0.00001344944],"domain_scores_gemma":[0.9999167,0.00001557673,0.00003609025,0.000004840334,0.00001808357,0.000008692493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005729674,0.000002170144,0.00002415202,0.00001534667,7.986871e-7,0.000008759735,0.000004651555,0.00002439364,0.9990344,0.0000220334,0.000006344724,0.0008512499],"study_design_scores_gemma":[0.000005839544,0.0001686246,0.001495601,0.000005611199,0.000008176808,0.0001348229,0.00001601755,0.001099656,0.9954479,0.00002448227,0.00158763,0.000005683648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735392,0.002924865,0.02164889,0.00007579941,0.00003243943,0.00009221986,0.0001466199,0.0001039183,0.001435985],"genre_scores_gemma":[0.9630178,0.001927753,0.03284739,0.00006559122,0.000007887496,0.00006475403,0.0001311305,0.00002082366,0.001916848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004586724,"threshold_uncertainty_score":0.001527548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08900163495022022,"score_gpt":0.4028146710531761,"score_spread":0.3138130361029559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}