{"id":"W4283010712","doi":"10.1038/s41591-022-01862-8","title":"Regenerative and restorative medicine for eye disease","year":2022,"lang":"en","type":"review","venue":"Nature Medicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Eye Institute; Research to Prevent Blindness","keywords":"Transplantation; Regenerative medicine; Macular degeneration; Retinal pigment epithelium; Retinal degeneration; Blindness; Progenitor cell; Retina; Neuroscience; Regeneration (biology); Retinal; Stem cell; Medicine; Biology; Ophthalmology; Optometry; Cell biology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003774939,0.000408072,0.0009085885,0.0001320592,0.0001608024,0.000005283829,0.0002234654,0.0003925991,0.0001540868],"category_scores_gemma":[0.001320902,0.0002618167,0.0001245661,0.0001934566,0.0002930865,0.000002214346,0.0001245543,0.0004905239,0.000001006704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003464617,"about_ca_system_score_gemma":0.0002687492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003314351,"about_ca_topic_score_gemma":0.000006738379,"domain_scores_codex":[0.9983951,0.0001431429,0.0003614196,0.0006169262,0.0002693589,0.0002140396],"domain_scores_gemma":[0.999068,0.0001097988,0.0002448613,0.0003060026,0.00008418099,0.0001872121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004383305,0.00005177862,0.00003958882,0.01045129,0.0005659352,0.00004121083,0.0003126827,4.246261e-7,0.0001270528,0.002325021,0.3040866,0.68156],"study_design_scores_gemma":[0.0006898446,0.0005609669,0.00001510668,0.001706811,0.0005129994,0.000004007096,0.0001009694,7.100376e-7,0.000006942537,0.0001768973,0.9959446,0.0002801081],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001988882,0.9949883,0.00009154182,0.001333396,0.0006409707,0.001012284,0.00006946256,0.00001096037,0.001833146],"genre_scores_gemma":[0.00003365114,0.9864144,0.000143028,0.0007403108,0.001355879,0.0003718912,0.005247085,0.00004860655,0.005645203],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.691858,"threshold_uncertainty_score":0.9999834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03263934133107702,"score_gpt":0.3845662175928361,"score_spread":0.3519268762617591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}