{"id":"W4283013320","doi":"10.1038/s41598-022-14248-0","title":"Mid-pregnancy poly(I:C) viral mimic disrupts placental ABC transporter expression and leads to long-term offspring motor and cognitive dysfunction","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Bill and Melinda Gates Foundation","keywords":"Offspring; ABCG1; Transplacental; Pregnancy; Placenta; Endocrinology; Andrology; Biology; Transporter; Internal medicine; Fetus; Medicine; ABCA1; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001466609,0.000450819,0.000337153,0.0003517325,0.0001762152,0.0003933934,0.0002744531,0.0004331112,0.001567684],"category_scores_gemma":[0.0001366412,0.0002519092,0.0003675347,0.0001433285,0.0003705819,0.0002312633,0.0002362619,0.001134202,0.0004580085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005274229,"about_ca_system_score_gemma":0.0002939566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001167044,"about_ca_topic_score_gemma":0.001548162,"domain_scores_codex":[0.9997485,0.0000288511,0.0000293547,0.00008247771,0.00005003489,0.00006073538],"domain_scores_gemma":[0.9997761,0.00002458914,0.0001074272,0.00002085894,0.0000144115,0.00005668161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003596381,0.00007673209,0.0003098316,0.00004058424,0.000008090009,0.0001546164,0.00003017614,0.00005570922,0.9973367,0.00009395262,0.00006842268,0.001465567],"study_design_scores_gemma":[0.00004296333,0.002216784,0.01295699,0.00003293767,0.00005216109,0.0009832594,0.000131389,0.001421481,0.9789827,0.0001383205,0.003026457,0.00001456433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914919,0.002264092,0.003099991,0.0001905508,0.00008235133,0.00004639713,0.001091411,0.0001994114,0.001533886],"genre_scores_gemma":[0.9879553,0.002128856,0.002215704,0.0001476221,0.00001389315,0.000131769,0.001109412,0.00004963914,0.006247759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001567684,"threshold_uncertainty_score":0.005244434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591105262987937,"score_gpt":0.2631173183448068,"score_spread":0.2472062657149274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}