{"id":"W4283013998","doi":"10.3389/fpsyt.2022.871997","title":"Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder","year":2022,"lang":"en","type":"review","venue":"Frontiers in Psychiatry","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research","keywords":"Microglia; Neuroinflammation; Neuroscience; Inflammation; Context (archaeology); Major depressive disorder; Biology; Medicine; Immunology; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002440761,0.0005637566,0.0009996796,0.0008733507,0.0002668298,0.0001236702,0.0006048631,0.0002601569,0.00009429006],"category_scores_gemma":[0.0000553566,0.0005093589,0.0002583537,0.0007381724,0.00008879896,0.0002238673,0.0001984586,0.0008916748,0.00001417947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006901678,"about_ca_system_score_gemma":0.0003049115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003662462,"about_ca_topic_score_gemma":0.00001752592,"domain_scores_codex":[0.996308,0.0009408721,0.0009390604,0.001094573,0.0002776739,0.000439864],"domain_scores_gemma":[0.9986663,0.0000834129,0.0005435466,0.0005967771,0.00001125886,0.00009872367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000565159,0.0002487569,0.0004065209,0.00177206,0.00002801722,0.00003795742,0.000342462,0.00002654786,0.004458654,0.007663077,0.001209473,0.98375],"study_design_scores_gemma":[0.001530573,0.00005802418,0.0001565914,0.0003460716,0.0001097083,0.0001669905,0.0001413384,0.0003348438,0.001056816,0.00548611,0.989801,0.0008119613],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003620464,0.9826664,0.001297925,0.0001314906,0.01021078,0.001723613,0.0001680427,0.0001040119,0.0000772838],"genre_scores_gemma":[0.0005310331,0.9974887,0.0003830105,0.0004503038,0.0002473414,0.0006479562,0.00005761294,0.0001147544,0.00007926794],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9885915,"threshold_uncertainty_score":0.9997358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126142542800687,"score_gpt":0.2614799963856669,"score_spread":0.24021857095766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}