{"id":"W4283013998","doi":"10.3389/fpsyt.2022.871997","title":"Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder","year":2022,"lang":"en","type":"review","venue":"Frontiers in Psychiatry","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research","keywords":"Microglia; Neuroinflammation; Neuroscience; Inflammation; Context (archaeology); Major depressive disorder; Biology; Medicine; Immunology; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003562266,0.0006685386,0.0009656551,0.001310967,0.0002177497,0.0006469403,0.000593086,0.0009326097,0.001982221],"category_scores_gemma":[0.0003826253,0.0001712732,0.0003826634,0.001161578,0.000282733,0.0006312031,0.000549114,0.001212429,0.001215101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004780817,"about_ca_system_score_gemma":0.000683434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008440687,"about_ca_topic_score_gemma":0.001993282,"domain_scores_codex":[0.9999062,0.00002136481,0.00001517829,0.00001529979,0.00003010548,0.0000118301],"domain_scores_gemma":[0.9999028,0.00003791093,0.00001568665,0.000002742272,0.00002748293,0.0000132412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001435198,0.00007874442,0.0001695034,0.01770178,0.00008213895,0.0002853222,0.00006408969,0.0003253014,0.002074512,0.002818409,0.02819488,0.9480619],"study_design_scores_gemma":[0.00005866261,0.000249223,0.002672492,0.007178144,0.0002243462,0.002783647,0.00009370103,0.0002050554,0.0007204702,0.003351714,0.9824319,0.00003075925],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007854844,0.9992265,0.00004079254,0.0001695871,0.0001007662,0.00000224518,0.000008411612,0.000003630875,0.0003696168],"genre_scores_gemma":[0.0006883332,0.9986398,0.00009038275,0.0001445393,0.0001418923,0.000005108192,0.00001564707,6.825357e-7,0.0002736582],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001982221,"threshold_uncertainty_score":0.006631136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126142542800687,"score_gpt":0.2614799963856669,"score_spread":0.24021857095766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}