{"id":"W4283014891","doi":"10.21203/rs.3.rs-1685544/v1","title":"Defective type I interferon immunity is associated with increasing COVID-19 severity","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Mercatus Center, George Mason University; Health Service Executive; Institut des maladies génétiques Imagine; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; Wellcome Trust; European Commission; Canadian Institute for Theoretical Astrophysics; Institut National de la Santé et de la Recherche Médicale; Fondation du Souffle; Fondation pour la Recherche Médicale; JPB Foundation; Science Foundation Ireland; Health Research Board; St. Giles Foundation; George Mason University; National Institutes of Health; Fisher Center for Alzheimer's Research Foundation; Georgia Clinical and Translational Science Alliance; Howard Hughes Medical Institute","keywords":"Coronavirus disease 2019 (COVID-19); Interferon; Immunity; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; 2019-20 coronavirus outbreak; Interferon type I; Immunology; Medicine; Biology; Immune system; Internal medicine; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002055987,0.0003166146,0.0003892718,0.0005029217,0.0002628569,0.0004177867,0.0001290002,0.0002756639,0.002465933],"category_scores_gemma":[0.0005252277,0.0001459011,0.0002384014,0.0003551803,0.00018274,0.0001678802,0.0004185726,0.0005753776,0.0002869288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001501966,"about_ca_system_score_gemma":0.0000959785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003022804,"about_ca_topic_score_gemma":0.0003067992,"domain_scores_codex":[0.9997674,0.00003644586,0.00004170647,0.00005623718,0.00004858592,0.00004966928],"domain_scores_gemma":[0.9991292,0.00007176115,0.000394985,0.00004053593,0.00008718407,0.0002764029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001937416,0.000124639,0.9227277,0.00005874836,0.00006850364,0.0005055178,0.0001095483,0.00005818954,0.0711446,0.00004010973,0.0001517376,0.003073278],"study_design_scores_gemma":[0.000006560746,0.0004098378,0.9954464,0.000005551798,0.00001364951,0.0008326871,0.00009495018,0.0001410414,0.002867011,0.00002323767,0.000155288,0.000003645485],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992096,0.0001738834,0.0001563874,0.000012552,0.000004402756,0.00001049206,0.0002032839,0.000006021759,0.0002232266],"genre_scores_gemma":[0.9992967,0.00006442247,0.0001433552,0.00001389233,0.00000716219,0.000008107361,0.0003079621,0.000002062079,0.0001562777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002465933,"threshold_uncertainty_score":0.008249342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1806588474103277,"score_gpt":0.5262048010070708,"score_spread":0.3455459535967431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}