{"id":"W4283016030","doi":"10.1200/po.21.00561","title":"Locoregionally Advanced, BRAF V600L–Positive, Mucosal Melanoma of the Hypopharynx Treated With a Combination of <i>BRAF</i> and <i>MEK</i> Inhibitors","year":2022,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont; Université de Sherbrooke","funders":"","keywords":"Mucosal melanoma; Medicine; Melanoma; Cancer research; MEK inhibitor; Trametinib; Dermatology; Oncology; Internal medicine; Biology; Genetics; MAPK/ERK pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001574448,0.0003273489,0.000692548,0.0002674877,0.0003344042,0.0002894427,0.0002230118,0.0003169423,0.002368805],"category_scores_gemma":[0.00016174,0.0001604571,0.0005990894,0.0002456717,0.0001789496,0.0003158236,0.0001658769,0.0006451104,0.0004254478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005138541,"about_ca_system_score_gemma":0.0003782744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0033736,"about_ca_topic_score_gemma":0.01400849,"domain_scores_codex":[0.9999483,0.000006703056,0.00000371133,0.000008325302,0.00001820037,0.00001478536],"domain_scores_gemma":[0.9999372,0.00000864487,0.00001009677,0.00000523202,0.000006722873,0.00003208524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.0683504,0.006626637,0.06510907,0.001774425,0.001669029,0.05653277,0.0005640027,0.0030992,0.215375,0.000536054,0.03902687,0.5413365],"study_design_scores_gemma":[0.01503768,0.1160899,0.7020094,0.001028104,0.003093156,0.05994279,0.0006387135,0.00646828,0.02470154,0.0006073446,0.07025685,0.0001263195],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9400515,0.03556762,0.000705174,0.002043561,0.000567767,0.000322982,0.000514921,0.000206592,0.02001979],"genre_scores_gemma":[0.9820877,0.008984372,0.0008417196,0.001082247,0.0002821083,0.00007363244,0.0008009929,0.00001945465,0.005827833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0033736,"threshold_uncertainty_score":0.007924438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005415797021471048,"score_gpt":0.2185437082643317,"score_spread":0.2131279112428607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}