{"id":"W4283016030","doi":"10.1200/po.21.00561","title":"Locoregionally Advanced, BRAF V600L–Positive, Mucosal Melanoma of the Hypopharynx Treated With a Combination of <i>BRAF</i> and <i>MEK</i> Inhibitors","year":2022,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont; Université de Sherbrooke","funders":"","keywords":"Mucosal melanoma; Medicine; Melanoma; Cancer research; MEK inhibitor; Trametinib; Dermatology; Oncology; Internal medicine; Biology; Genetics; MAPK/ERK pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002404432,0.0001538338,0.0002776239,0.00006588749,0.0001349043,0.000004158973,0.0002410538,0.0001249492,0.00003142993],"category_scores_gemma":[0.00005013301,0.000112035,0.00008376331,0.0001697165,0.0002111334,0.000007514435,0.0003854569,0.0001417117,7.514805e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003659974,"about_ca_system_score_gemma":0.0001954583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000273144,"about_ca_topic_score_gemma":0.00004217605,"domain_scores_codex":[0.9986186,0.0002908779,0.0003316411,0.0003383983,0.0002558659,0.0001646025],"domain_scores_gemma":[0.9990396,0.0001081845,0.000346196,0.0003065516,0.0001426825,0.00005677589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002095826,0.0006109289,0.01740189,0.00002455981,0.00006665793,0.00001765578,0.0001421637,0.000150012,0.9436401,0.0005987172,0.003190242,0.03206126],"study_design_scores_gemma":[0.007153764,0.01312557,0.04533814,0.00004639921,0.00009153878,0.0004652546,0.0003036583,0.00008878102,0.8416803,0.0005185712,0.0908541,0.0003338692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956542,0.0004499777,0.000138638,0.0003027361,0.0001847356,0.0004785898,0.0001342629,0.000007799819,0.002649077],"genre_scores_gemma":[0.9985128,0.0000720382,0.0004585423,0.0002797248,0.00003991623,0.00007594706,0.0001232348,0.00001948928,0.0004182815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1019597,"threshold_uncertainty_score":0.4568654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005415797021471048,"score_gpt":0.2185437082643317,"score_spread":0.2131279112428607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}