{"id":"W4283022960","doi":"10.1016/j.str.2022.05.020","title":"Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection","year":2022,"lang":"en","type":"article","venue":"Structure","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institute on Aging; National Cancer Institute; National Institutes of Health; National Institute on Drug Abuse; Canada Research Chairs","keywords":"BRD4; Infectivity; Bromodomain; Acetylation; Biology; Cell biology; Plasma protein binding; Histone acetyltransferase; Virology; Chemistry; Virus; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002098157,0.0003303974,0.0003314031,0.0002186582,0.0002804053,0.0004453819,0.0002962298,0.0003198637,0.00226108],"category_scores_gemma":[0.000235434,0.0003017025,0.0004081723,0.0001464073,0.000188186,0.000166775,0.0001954688,0.0004377799,0.000959586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009491963,"about_ca_system_score_gemma":0.0004467171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001994679,"about_ca_topic_score_gemma":0.002323985,"domain_scores_codex":[0.9997537,0.00005593345,0.0000252323,0.00003227811,0.00006262463,0.00007034929],"domain_scores_gemma":[0.999884,0.00002185892,0.00002631682,0.00002053546,0.0000198565,0.00002737422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003421721,0.000040928,0.0002924562,0.00003393106,0.000008583034,0.00007382379,0.000008334248,0.000105264,0.9979916,0.0001575756,0.0001498495,0.0007954985],"study_design_scores_gemma":[0.00003487626,0.0001051848,0.007790755,0.000005583926,0.000008809439,0.0004327285,0.0000178873,0.001669949,0.9855504,0.00004765269,0.004329844,0.000006221145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906402,0.002371692,0.003286085,0.0003509002,0.00007874537,0.00004192878,0.0008489396,0.0001330486,0.002248467],"genre_scores_gemma":[0.9874691,0.0006623103,0.003284256,0.0001032014,0.00001233086,0.00002660754,0.002645839,0.00004355154,0.00575273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00226108,"threshold_uncertainty_score":0.007564068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129473904156996,"score_gpt":0.2767088509232983,"score_spread":0.2654141118817284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}