{"id":"W4283022960","doi":"10.1016/j.str.2022.05.020","title":"Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection","year":2022,"lang":"en","type":"article","venue":"Structure","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institute on Aging; National Cancer Institute; National Institutes of Health; National Institute on Drug Abuse; Canada Research Chairs","keywords":"BRD4; Infectivity; Bromodomain; Acetylation; Biology; Cell biology; Plasma protein binding; Histone acetyltransferase; Virology; Chemistry; Virus; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005979432,0.00007196951,0.00006386745,0.00003112888,0.0002414372,0.0000101533,0.0001353112,0.00005185201,0.00005324842],"category_scores_gemma":[0.0000278268,0.000058257,0.00007020944,0.0001156761,0.00002228381,0.000002070103,0.0001571973,0.00007290312,4.403677e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001578226,"about_ca_system_score_gemma":0.00003975362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000319798,"about_ca_topic_score_gemma":0.00004068132,"domain_scores_codex":[0.9994797,0.00003441794,0.0001157428,0.0001653793,0.0001077906,0.00009699627],"domain_scores_gemma":[0.9996798,0.000001066845,0.00007834614,0.0001895721,0.00003823013,0.00001299491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002128133,0.000006414995,0.0002812598,0.00001307562,0.00001287769,5.324139e-8,0.00006347982,0.00001108026,0.9921939,0.0002241932,0.006574202,0.0005982166],"study_design_scores_gemma":[0.0001882362,0.0001153465,0.0004495919,0.000003829516,0.000004705007,0.000002636973,0.00001533374,0.00000253648,0.8887679,0.000268041,0.1101137,0.0000681497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998269,0.00001956377,0.0003078278,0.0002957798,0.000252738,0.0005889134,0.0001387453,0.000005453252,0.0001220269],"genre_scores_gemma":[0.9985041,5.240472e-7,0.0002748673,0.0003552585,0.0001501069,0.00007228109,0.0000825867,0.00001133574,0.0005489517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1035395,"threshold_uncertainty_score":0.2375651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129473904156996,"score_gpt":0.2767088509232983,"score_spread":0.2654141118817284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}