{"id":"W4283026383","doi":"10.1007/s11523-022-00888-9","title":"Cobimetinib in Pediatric and Young Adult Patients with Relapsed or Refractory Solid Tumors (iMATRIX-cobi): A Multicenter, Phase I/II Study","year":2022,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"National Cancer Institute; Genentech; F. Hoffmann-La Roche","keywords":"Medicine; Refractory (planetary science); Multicenter study; Phases of clinical research; Internal medicine; Oncology; Clinical trial; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003041304,0.0002466843,0.0003832438,0.0001802256,0.0002558393,0.000009195833,0.0002230135,0.0001282495,0.0001167869],"category_scores_gemma":[0.0001664222,0.0002092585,0.00004231718,0.000253646,0.00006013284,0.000007883665,0.0004000102,0.0003350294,0.000004257279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009085838,"about_ca_system_score_gemma":0.0002767717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000101137,"about_ca_topic_score_gemma":0.0005519096,"domain_scores_codex":[0.9979176,0.0004137272,0.0004403475,0.000595669,0.0002103869,0.0004222733],"domain_scores_gemma":[0.9991447,0.00003871946,0.0002577488,0.0003163861,0.0001097259,0.0001327069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.03355131,0.02647717,0.8667189,0.00009512214,0.0002162838,0.0009448751,0.00394666,0.00005321165,0.05548177,0.00001776027,0.005509992,0.006986885],"study_design_scores_gemma":[0.1872081,0.4163064,0.3335223,0.00002674535,0.0005769237,0.0002268893,0.0114979,0.0006130118,0.007605448,0.00002533105,0.04003537,0.002355564],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977524,0.0002433422,0.00001222522,0.00003180919,0.000389837,0.001078364,0.0001084378,0.00002556382,0.0003580581],"genre_scores_gemma":[0.9981713,0.00005678477,0.0003357375,0.000216694,0.0001193673,0.0003037534,0.0003920528,0.0000398312,0.000364428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5331967,"threshold_uncertainty_score":0.8533313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008484783094617332,"score_gpt":0.271109531333761,"score_spread":0.2626247482391437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}