{"id":"W4283026383","doi":"10.1007/s11523-022-00888-9","title":"Cobimetinib in Pediatric and Young Adult Patients with Relapsed or Refractory Solid Tumors (iMATRIX-cobi): A Multicenter, Phase I/II Study","year":2022,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"National Cancer Institute; Genentech; F. Hoffmann-La Roche","keywords":"Medicine; Refractory (planetary science); Multicenter study; Phases of clinical research; Internal medicine; Oncology; Clinical trial; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001230386,0.0008825727,0.001348476,0.0002348117,0.0002500215,0.0005309952,0.000407523,0.0004591137,0.000896653],"category_scores_gemma":[0.0005034858,0.0003090697,0.000696842,0.0003409209,0.0003341776,0.0004271804,0.0002202134,0.001609174,0.0003535744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007170174,"about_ca_system_score_gemma":0.001407789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009891071,"about_ca_topic_score_gemma":0.002809786,"domain_scores_codex":[0.999774,0.00009623088,0.00001893415,0.00003268204,0.00003092754,0.00004718338],"domain_scores_gemma":[0.9995516,0.00003828857,0.0001250222,0.00002573929,0.00003396715,0.0002253658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3652004,0.07223995,0.07875925,0.001632281,0.002825988,0.001708574,0.001051242,0.005158389,0.1396117,0.0005275343,0.01026029,0.3210243],"study_design_scores_gemma":[0.2631934,0.569565,0.1329261,0.0001220498,0.001426132,0.002845299,0.000240194,0.004021308,0.01429567,0.0001940476,0.01111322,0.00005759365],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960134,0.002168765,0.0001734304,0.0001883553,0.0000242246,0.0005120433,0.0003625898,0.00003252339,0.0005246917],"genre_scores_gemma":[0.9916163,0.003437155,0.001293587,0.0004976447,0.00009179586,0.000903154,0.001503762,0.00001576157,0.0006408363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001348476,"threshold_uncertainty_score":0.006506979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008484783094617332,"score_gpt":0.271109531333761,"score_spread":0.2626247482391437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}