{"id":"W4283026547","doi":"10.1101/gad.349489.122","title":"Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the <i>Sox2</i> locus","year":2022,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"H2020 European Research Council; Agence Nationale de la Recherche; National Human Genome Research Institute; Institute of Genetics; National Institutes of Health; Oncode Institute; Canadian Institutes of Health Research; KWF Kankerbestrijding; Canada Foundation for Innovation; Institut National de la Santé et de la Recherche Médicale; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; European Commission","keywords":"Biology; Chromatin; Locus (genetics); Genetics; Architecture; SOX2; Regulation of gene expression; Computational biology; Transcription factor; Evolutionary biology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001443698,0.0002409926,0.00022417,0.0002102348,0.0001996391,0.0006148061,0.0002289016,0.0001869028,0.0008240427],"category_scores_gemma":[0.0002092283,0.0002202304,0.0001926701,0.0001357722,0.0005251574,0.0003499999,0.000360802,0.0003450546,0.0002715717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002650789,"about_ca_system_score_gemma":0.0002040751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004265381,"about_ca_topic_score_gemma":0.0009187878,"domain_scores_codex":[0.9997805,0.00002241239,0.00001357985,0.00008153901,0.0000641438,0.00003786691],"domain_scores_gemma":[0.9997969,0.00003036781,0.0000585533,0.00003171062,0.00002119457,0.00006124342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003484493,0.000002596224,0.0008062484,0.000008366022,0.000001785413,0.00001904805,0.00001177674,0.00003275461,0.9982561,0.0001616647,0.000006431823,0.0006583154],"study_design_scores_gemma":[0.00002902746,0.0001382164,0.1027115,0.00001062594,0.00002185006,0.0008175197,0.00009410046,0.001733563,0.8919933,0.0005742109,0.001859237,0.00001692785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928639,0.0004840869,0.004719646,0.00005302959,0.000007703603,0.000004966984,0.0001408634,0.00008451538,0.001641249],"genre_scores_gemma":[0.9979359,0.0001347178,0.0008057196,0.00001705971,0.000005456731,0.000005391986,0.0002045987,0.00002106545,0.0008701042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008240427,"threshold_uncertainty_score":0.002756655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004825319255560043,"score_gpt":0.1803223806972752,"score_spread":0.1754970614417151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}