{"id":"W4283027133","doi":"10.1128/aac.00198-22","title":"<i>In Vitro</i> Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance","year":2022,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Montréal; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); In vitro; 2019-20 coronavirus outbreak; Virology; Selection (genetic algorithm); Betacoronavirus; Microbiology; Drug resistance; Resistance (ecology); Chemistry; Biology; Medicine; Genetics; Computer science; Outbreak","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002007006,0.0003517045,0.0003418895,0.0001434534,0.0001584763,0.0003801398,0.0001997085,0.0002343938,0.002139095],"category_scores_gemma":[0.0002386987,0.0001345746,0.0002793675,0.0001150564,0.0001461214,0.0001304914,0.0001794429,0.0005965016,0.001002299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002202915,"about_ca_system_score_gemma":0.0001153493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001170169,"about_ca_topic_score_gemma":0.001486369,"domain_scores_codex":[0.9997429,0.00008104761,0.00003543515,0.00004564797,0.00004833766,0.00004659551],"domain_scores_gemma":[0.999808,0.00006164314,0.00003325798,0.00004117617,0.00003138705,0.00002459912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005439339,0.00002451905,0.0002771954,0.00001140346,0.00000271696,0.00004092779,0.00001329413,0.00004457379,0.9988614,0.00006319518,0.0001398317,0.0004665116],"study_design_scores_gemma":[0.000004953371,0.0002078978,0.002006331,0.000002842618,0.000006060546,0.000287122,0.00001740946,0.0004255032,0.9954987,0.00001606091,0.001524205,0.00000285851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841565,0.0009720647,0.006117156,0.000290296,0.00008282283,0.00006925825,0.002228852,0.0001989287,0.005884066],"genre_scores_gemma":[0.9785018,0.0006428597,0.009646327,0.0001943663,0.00003156791,0.00007222909,0.004756133,0.0001011977,0.006053449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002139095,"threshold_uncertainty_score":0.007155955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01919992916647966,"score_gpt":0.300734689882064,"score_spread":0.2815347607155843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}